关于 2 型糖尿病患者对 COVID-19 疫苗的弱免疫反应的研究进展。

IF 1.5 4区医学 Q4 IMMUNOLOGY Viral immunology Pub Date : 2024-03-01 DOI:10.1089/vim.2023.0097

Shiqi Yuan, Wenwen He, Bin Liu, Zhuoran Liu

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引用次数: 0

摘要

冠状病毒病 2019（COVID-19）在人群中普遍易感，传染性强，传播速度快，致死率高。目前缺乏针对该病毒的特效药物，接种疫苗是预防感染的最有效策略。但研究发现，部分人群尤其是糖尿病患者对各种 COVID-19 疫苗表现出不同程度的弱免疫反应性，导致糖尿病患者对新型冠状病毒的预防效果不佳。因此，本研究对近年来对 COVID-19 疫苗免疫反应较弱的 2 型糖尿病（T2DM）患者进行了分析。本文综述了T2DM患者对疫苗反应弱的现象、初步机制及相关影响因素，希望对COVID-19高危人群新疫苗的研发有所帮助。

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Research Progress on the Weak Immune Response to the COVID-19 Vaccine in Patients with Type 2 Diabetes.

Coronavirus Disease 2019 (COVID-19) is generally susceptible to the population, highly infectious, rapidly transmitted, and highly fatal. There is a lack of specific drugs against the virus at present and vaccination is the most effective strategy to prevent infection. However, studies have found that some groups, particularly patients with diabetes, show varying degrees of weak immune reactivity to various COVID-19 vaccines, resulting in poor preventive efficacy against the novel coronavirus in patients with diabetes. Therefore, in this study, patients with type 2 diabetes mellitus (T2DM) who had weak immune response to the COVID-19 vaccine in recent years were analyzed. This article reviews the phenomenon, preliminary mechanism, and related factors affecting weak vaccine response in patients with T2DM, which is expected to help in the development of new vaccines for high-risk groups for COVID-19.

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来源期刊

Viral immunology 医学-病毒学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Viral Immunology delivers cutting-edge peer-reviewed research on rare, emerging, and under-studied viruses, with special focus on analyzing mutual relationships between external viruses and internal immunity. Original research, reviews, and commentaries on relevant viruses are presented in clinical, translational, and basic science articles for researchers in multiple disciplines. Viral Immunology coverage includes: Human and animal viral immunology Research and development of viral vaccines, including field trials Immunological characterization of viral components Virus-based immunological diseases, including autoimmune syndromes Pathogenic mechanisms Viral diagnostics Tumor and cancer immunology with virus as the primary factor Viral immunology methods.