日本药典》中龙胆草升华试验的结果化合物为 5-（羟甲基）糠醛

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL Journal of Natural Medicines Pub Date : 2024-03-19 DOI:10.1007/s11418-024-01802-5

Atsushi Tsuge, Yuto Goto, Sayaka Masada, Michiho Ito

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引用次数: 0

摘要

龙胆草是一种草药，在日本一直被用作胃肠道药物。在《日本药典》第 18 版中，升华试验被规定为龙胆草的鉴定试验。在升华试验中获得的化合物被认为是龙胆素，一种黄酮类化合物。然而，我们使用液相色谱-高分辨质谱法（LC-HRMS）以及 1H- 和 13C-NMR 鉴定出的化合物是 5-（羟甲基）糠醛（5-HMF）。该化合物是龙胆草（Gentianae Scabrae Radix）和龙胆草（Gentianae Macrophyllae Radix）的升华产物，与龙胆草同属。这些结果表明，有必要将龙胆草的鉴定试验修改为一种更独特的方法。

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Resultant compound from sublimation test for Gentianae Radix in Japanese Pharmacopoeia was 5-(hydroxymethyl)furfural

Gentianae Radix, an herbal medicine, has been used as a gastrointestinal drug in Japan. In the Japanese Pharmacopoeia 18th Revision, the sublimation test is specified as an identification test for Gentianae Radix. The compound obtained in this sublimation test was believed to be gentisin, a xanthone family compound. However, the compound we identified using liquid chromatography-high-resolution mass spectrometry (LC-HRMS) and ¹H- and ¹³C-NMR was 5-(hydroxymethyl)furfural (5-HMF). The same compound was found to be a sublimate of Gentianae Scabrae Radix and Gentianae Macrophyllae Radix, belonging to the same genus as Gentianae Radix. These results indicate the necessity to revise the identification test for Gentianae Radix to a more unique method.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.