Pub Date : 2026-03-26DOI: 10.1007/s11418-025-01978-4
Ning Li, Qian He, Cunwu W Chen, Qun Zhao, Yanfei F He
{"title":"Anti-asthmatic effects and ingredient annotation of the active fraction from Ganoderma lucidum.","authors":"Ning Li, Qian He, Cunwu W Chen, Qun Zhao, Yanfei F He","doi":"10.1007/s11418-025-01978-4","DOIUrl":"https://doi.org/10.1007/s11418-025-01978-4","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147519804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-21DOI: 10.1007/s11418-026-02030-9
Ekaterina A Yurchenko, Anastasia B Kozhushnaya, Sophia A Kolesnikova, Ekaterina A Chingizova, Ekaterina S Menchinskaya, Evgeny A Pislyagin, Aleksandra S Kuzmich, Dmitry L Aminin
{"title":"Biological activity of isomalabaricane compounds from the marine sponge Rhabdastrella globostellata.","authors":"Ekaterina A Yurchenko, Anastasia B Kozhushnaya, Sophia A Kolesnikova, Ekaterina A Chingizova, Ekaterina S Menchinskaya, Evgeny A Pislyagin, Aleksandra S Kuzmich, Dmitry L Aminin","doi":"10.1007/s11418-026-02030-9","DOIUrl":"https://doi.org/10.1007/s11418-026-02030-9","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-21DOI: 10.1007/s11418-026-02024-7
Weijun Chen, Nuan Dong, Xue Lu, Dongmei Qin
{"title":"The mechanism of the water layer extract of Cichorium pumilum Jacq water extract in the treatment of Hepatic fibrosis was investigated using HPLC-MS/MS and network pharmacology.","authors":"Weijun Chen, Nuan Dong, Xue Lu, Dongmei Qin","doi":"10.1007/s11418-026-02024-7","DOIUrl":"https://doi.org/10.1007/s11418-026-02024-7","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Resin glycosides are characteristically present in Convolvulaceae plants. We recently demonstrated that three genuine resin glycosides, muricatins V, VI, and IX, from the seeds of Ipomoea muricata, inhibit lipase. This study investigated whether the resin glycoside fraction (CHRG Fr.) obtained from the whole plants of Calystegia hederacea and three resin glycosides, calyhedins II (1), III (2), and VIII (3), from the rhizomes of this plant, can inhibit porcine lipase in vitro. The results indicated the inhibitory effects of CHRG Fr. (IC50; 33.1 µg/mL) and 1-3 (IC50; 4.5-23.7 µM). In silico molecular docking simulations revealed that 1-3 bind stably to the catalytic sites of porcine (PDB ID: 1ETH) and human (PDB ID: 1LPB) pancreatic lipases. Using data from 1 to 3 and three muricatins that we had previously determined, we observed a high correlation (R2 = 0.817, log10 (a; IC50 value) = 0.472799 x (b; docking score) + 5.9412, n = 6) between in vitro IC50 values and in silico binding scores for porcine lipase. By a leave-one-out cross-validation approach, we confirmed that this equation is a useful model with moderate predictive performance. There was also a high correlation (R2 = 0.928) in binding scores between porcine and human lipases. In conclusion, this study is the first to demonstrate that 1-3 from C. hederacea can inhibit porcine lipase in vitro and bind stably to lipase catalytic sites in silico. Therefore, it is suggested that resin glycosides from C. hederacea may serve as unique lipase inhibitors. (246 words).
{"title":"Inhibitory effects of three genuine resin glycosides from Calystegia hederacea on in vitro porcine lipase assay and in silico docking simulation analysis.","authors":"Hirotaka Nishikawa, Masashi Hirano, Hideki Kinoshita, Kazunari Yoneda, Masateru Ono, Shin Yasuda","doi":"10.1007/s11418-026-02017-6","DOIUrl":"https://doi.org/10.1007/s11418-026-02017-6","url":null,"abstract":"<p><p>Resin glycosides are characteristically present in Convolvulaceae plants. We recently demonstrated that three genuine resin glycosides, muricatins V, VI, and IX, from the seeds of Ipomoea muricata, inhibit lipase. This study investigated whether the resin glycoside fraction (CHRG Fr.) obtained from the whole plants of Calystegia hederacea and three resin glycosides, calyhedins II (1), III (2), and VIII (3), from the rhizomes of this plant, can inhibit porcine lipase in vitro. The results indicated the inhibitory effects of CHRG Fr. (IC<sub>50</sub>; 33.1 µg/mL) and 1-3 (IC<sub>50</sub>; 4.5-23.7 µM). In silico molecular docking simulations revealed that 1-3 bind stably to the catalytic sites of porcine (PDB ID: 1ETH) and human (PDB ID: 1LPB) pancreatic lipases. Using data from 1 to 3 and three muricatins that we had previously determined, we observed a high correlation (R<sup>2</sup> = 0.817, log<sub>10</sub> (a; IC<sub>50</sub> value) = 0.472799 x (b; docking score) + 5.9412, n = 6) between in vitro IC<sub>50</sub> values and in silico binding scores for porcine lipase. By a leave-one-out cross-validation approach, we confirmed that this equation is a useful model with moderate predictive performance. There was also a high correlation (R<sup>2</sup> = 0.928) in binding scores between porcine and human lipases. In conclusion, this study is the first to demonstrate that 1-3 from C. hederacea can inhibit porcine lipase in vitro and bind stably to lipase catalytic sites in silico. Therefore, it is suggested that resin glycosides from C. hederacea may serve as unique lipase inhibitors. (246 words).</p>","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147388984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-03-09DOI: 10.1007/s11418-026-02015-8
Md Ashiq Mahmud, Mohamed M Mohyeldin, Md Towhidul Islam Tarun, Abu Bakar Siddique, Sitanshu S Singh, Khalid A El Sayed
{"title":"Olive (Olea europaea) phenolics for the control of psoriasis via targeting SMYD2 and IL-17A protein-protein interaction networks.","authors":"Md Ashiq Mahmud, Mohamed M Mohyeldin, Md Towhidul Islam Tarun, Abu Bakar Siddique, Sitanshu S Singh, Khalid A El Sayed","doi":"10.1007/s11418-026-02015-8","DOIUrl":"https://doi.org/10.1007/s11418-026-02015-8","url":null,"abstract":"","PeriodicalId":654,"journal":{"name":"Journal of Natural Medicines","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147375739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号