揭示血管张力调节的复杂性:将化学-机械-生物途径与心血管生物力学相结合的多尺度计算方法。

IF 3 3区 医学 Q2 BIOPHYSICS Biomechanics and Modeling in Mechanobiology Pub Date : 2024-03-20 DOI:10.1007/s10237-024-01826-6
Michele Marino, Bastien Sauty, Giuseppe Vairo
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引用次数: 0

摘要

血管张力调节是心血管生理学的一个重要方面,对心血管的整体健康有着重要影响。然而,调节平滑肌细胞收缩和松弛的确切生理机制仍不确定。血管张力调节的复杂性源于其多尺度和多因素的性质,涉及整体血液动力学、局部流动条件、组织力学和生化途径。弥合这一知识鸿沟并将其转化为临床实践是一项挑战。本文提出了一个将化学-机械-生物途径与心血管生物力学相结合的计算模型,旨在揭示血管张力调节的复杂性。计算框架结合了全局血流动力学代数描述和血管节段尺度的详细有限元分析,以描述其被动和主动机械响应,以及由血管壁剪切应力引发的与化学生物途径相关的分子运输问题。它们之间的耦合是通过考虑双向相互作用来解释的。具体来说,重点是一氧化氮相关分子通路的作用,它们在调节平滑肌收缩和松弛以保持血管张力方面起着至关重要的作用。计算框架用于研究特定血管段生物力学反应的局部改变(如钙化或内皮功能障碍引起的生物力学反应)与更广泛的整体血流动力学条件之间的相互作用--无论是在基础状态下还是在改变状态下。所提议的方法旨在推进我们对血管张力调节及其对心血管健康影响的理解。通过将化学-机械-生物机制纳入硅学模型,这项研究使我们能够研究心血管对多因素刺激的反应,并将适应性平衡的作用纳入计算生物力学框架。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Unraveling the complexity of vascular tone regulation: a multiscale computational approach to integrating chemo-mechano-biological pathways with cardiovascular biomechanics

Vascular tone regulation is a crucial aspect of cardiovascular physiology, with significant implications for overall cardiovascular health. However, the precise physiological mechanisms governing smooth muscle cell contraction and relaxation remain uncertain. The complexity of vascular tone regulation stems from its multiscale and multifactorial nature, involving global hemodynamics, local flow conditions, tissue mechanics, and biochemical pathways. Bridging this knowledge gap and translating it into clinical practice presents a challenge. In this paper, a computational model is presented to integrate chemo-mechano-biological pathways with cardiovascular biomechanics, aiming to unravel the intricacies of vascular tone regulation. The computational framework combines an algebraic description of global hemodynamics with detailed finite element analyses at the scale of vascular segments for describing their passive and active mechanical response, as well as the molecular transport problem linked with chemo-biological pathways triggered by wall shear stresses. Their coupling is accounted for by considering a two-way interaction. Specifically, the focus is on the role of nitric oxide-related molecular pathways, which play a critical role in modulating smooth muscle contraction and relaxation to maintain vascular tone. The computational framework is employed to examine the interplay between localized alterations in the biomechanical response of a specific vessel segment—such as those induced by calcifications or endothelial dysfunction–and the broader global hemodynamic conditions—both under basal and altered states. The proposed approach aims to advance our understanding of vascular tone regulation and its impact on cardiovascular health. By incorporating chemo-mechano-biological mechanisms into in silico models, this study allows us to investigate cardiovascular responses to multifactorial stimuli and incorporate the role of adaptive homeostasis in computational biomechanics frameworks.

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来源期刊
Biomechanics and Modeling in Mechanobiology
Biomechanics and Modeling in Mechanobiology 工程技术-工程:生物医学
CiteScore
7.10
自引率
8.60%
发文量
119
审稿时长
6 months
期刊介绍: Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.
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