Addressing catheter lock therapy: Does heparin reduce the bioactivity of dalbavancin when together in solution during freezing?

The possible use of dalbavancin as a catheter lock solution was previously demonstrated by our study group. However, it was needed to assess whether heparin could affect dalbavancin bioactivity during freezing storage. We tested the bioactivity of a dalbavancin+heparin (DH) vs. dalbavancin () against Staphylococcal biofilms comparing DH median value of cfu counts and metabolic activity with that obtained for before and during storage under freezing up to 6 months. Despite there was a slight decrease in the median percentage reduction of metabolic activity at month 3 in between DH and (97.6 vs. 100, =0.037), considering the clinical criteria, no significant reduction in any of the variables tested was observed at the end of the experiment between and DH solutions. The addition of heparin to a dalbavancin lock solution did not affect its bioactivity against staphylococcal biofilms irrespective of its preservation time under freezing.