用结构域交换策略创建模块化转录调节器,实现基因网络中的新拓扑结构

IF 12.1 1区 工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnology advances Pub Date : 2024-03-19 DOI:10.1016/j.biotechadv.2024.108345
Clement T.Y. Chan , Vincenzo Kennedy , Sahaj Kinshuk
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引用次数: 0

摘要

转录调节器在生物信号和基因输出之间建立联系。在构建基因电路时,转录调节器可用于稳健地感知输入信号。然而,每个调控因子只能产生一个固定的连接,这对连接多个信号以实现更复杂的过程造成了限制。最近的研究发现,可以在各种调节器家族中应用域交换策略,创建模块化调节器,实现新的信号-输出连接,从而大大拓宽电路设计的可能性。在此,我们回顾了这一新兴策略的发展、利用由此产生的模块化调节器创造新的遗传响应行为,以及当前的局限性和进一步推进模块化调节器设计的解决方案。
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A domain swapping strategy to create modular transcriptional regulators for novel topology in genetic network

Transcriptional regulators generate connections between biological signals and genetic outputs. They are used robustly for sensing input signals in building genetic circuits. However, each regulator can only generate a fixed connection, which generates constraints in linking multiple signals for more complex processes. Recent studies discovered that a domain swapping strategy can be applied to various regulator families to create modular regulators for new signal-output connections, significantly broadening possibilities in circuit design. Here we review the development of this emerging strategy, the use of resulting modular regulators for creating novel genetic response behaviors, and current limitations and solutions for further advancing the design of modular regulators.

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来源期刊
Biotechnology advances
Biotechnology advances 工程技术-生物工程与应用微生物
CiteScore
25.50
自引率
2.50%
发文量
167
审稿时长
37 days
期刊介绍: Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.
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