在抗癌治疗心脏毒性的情况下,远程缺血调节对线粒体有保护作用吗?

IF 3.8 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Current Heart Failure Reports Pub Date : 2024-08-01 Epub Date: 2024-03-21 DOI:10.1007/s11897-024-00658-w
Petra Kleinbongard, Ioanna Andreadou
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引用次数: 0

摘要

综述的目的:综述(a)远程缺血调节(RIC)对线粒体的保护作用和(b)抗癌治疗对线粒体的损伤。然后,我们讨论了在抗癌治疗引起的心脏毒性中通过 RIC 保护线粒体的现有研究结果:在对健康小鼠和猪进行的三项实验研究中,RIC 对蒽环类药物诱导的心脏毒性有保护作用,而且有证据表明 RIC 改善了线粒体功能。在对癌症患者进行的两项研究中,RIC 介导的保护作用未得到证实。在成年癌症患者中,RIC 与不良预后有关。目前还没有关于癌症患者线粒体功能的数据。需要在肿瘤动物中进行研究,以确定 RIC 是否不会干扰药物的抗癌特性,以及 RIC 是否真的会改善线粒体功能,最终导致心脏功能的改善。
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Is There a Mitochondrial Protection via Remote Ischemic Conditioning in Settings of Anticancer Therapy Cardiotoxicity?

Purpose of review: To provide an overview of (a) protective effects on mitochondria induced by remote ischemic conditioning (RIC) and (b) mitochondrial damage caused by anticancer therapy. We then discuss the available results of studies on mitochondrial protection via RIC in anticancer therapy-induced cardiotoxicity.

Recent findings: In three experimental studies in healthy mice and pigs, there was a RIC-mediated protection against anthracycline-induced cardiotoxicity and there was some evidence of improved mitochondrial function with RIC. The RIC-mediated protection was not confirmed in the two available studies in cancer patients. In adult cancer patients, RIC was associated with an adverse outcome. There are no data on mitochondrial function in cancer patients. Studies in tumor-bearing animals are needed to determine whether RIC does not interfere with the anticancer properties of the drugs and whether RIC actually improves mitochondrial function, ultimately resulting in improved cardiac function.

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来源期刊
Current Heart Failure Reports
Current Heart Failure Reports Medicine-Emergency Medicine
CiteScore
5.30
自引率
0.00%
发文量
44
期刊介绍: This journal intends to provide clear, insightful, balanced contributions by international experts that review the most important, recently published clinical findings related to the diagnosis, treatment, management, and prevention of heart failure. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as investigative, pharmacologic, and nonpharmacologic therapies, pathophysiology, and prevention. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
期刊最新文献
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