Alliaxylines A-E: Five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss.

IF 2.5 4区医学 Q3 CHEMISTRY, MEDICINAL Journal of Natural Medicines Pub Date : 2024-03-22 DOI:10.1007/s11418-024-01794-2

Sandra Amalia Riyadi, Al Arofatus Naini, Tri Mayanti, Ronny Lesmana, Mohamad Nurul Azmi, Sofa Fajriah, Siriporn Jungsuttiwong, Unang Supratman

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摘要

从 Dysoxylum alliaceum (Blume) Blume ex.A.Juss.(Meliaceae）中分离并鉴定了这些化合物。这些化合物的结构是通过广泛的光谱分析（包括 HR-ESI-MS、UV、IR、1D 和 2D NMR）以及使用 DP4 + 算法对 NMR 移位进行理论推导而阐明的。因此，本研究旨在考察这些化合物对 MCF-7 和 A549 细胞株的细胞毒性活性。结果表明，化合物 2 对两种受测细胞的毒性最强，IC50 值分别为 34.95 ± 0.21 和 44.39 ± 1.03 µM。

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Alliaxylines A–E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss

A total of five new mexicanolides (1–5), namely alliaxylines A–E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI–MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC₅₀ values of 34.95 ± 0.21 and 44.39 ± 1.03 µM.

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来源期刊

Journal of Natural Medicines 医学-药学

CiteScore

6.90

自引率

3.00%

发文量

审稿时长

1.7 months

期刊介绍： The Journal of Natural Medicines is an international journal publishing original research in naturally occurring medicines and their related foods and cosmetics. It covers: -chemistry of natural products -biochemistry of medicinal plants -pharmacology of natural products and herbs, including Kampo formulas and traditional herbs -botanical anatomy -cultivation of medicinal plants. The journal accepts Original Papers, Notes, Rapid Communications and Natural Resource Letters. Reviews and Mini-Reviews are generally invited.