Agathis dammara 中的化合物通过增强葡萄糖摄取发挥降血糖作用：木酚素、萜烯等。

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL Natural Products and Bioprospecting Pub Date : 2024-03-22 DOI:10.1007/s13659-024-00440-4

Zhe-Wei Yu, Bang-Ping Cai, Su-Zhi Xie, Yi Zhang, Wen-Hui Wang, Shun-Zhi Liu, Yan-Lin Bin, Qi Chen, Mei-Juan Fang, Rong Qi, Ming-Yu Li, Ying-Kun Qiu

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摘要

本研究从 Agathis dammara 树林中分离出了两种新的贝壳杉烷二萜（16、17）以及 12 种木脂素（1-12）、一种三萜（15）和两种其他化合物（13、14）。利用 HR ESIMS 和一维/二维核磁共振光谱测定了新化合物的结构，并利用电子圆二色性（ECD）激子手性法测定了其绝对构型。化合物 5、11 和 14 在斑马鱼体内表现出显著的降血糖活性，其作用机制是增强斑马鱼的葡萄糖摄取。

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Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others

In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1–12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara. The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds 5, 11, 14 exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish.