利用四维磁共振成像评估肝纤维化家兔的主动脉血流动力学

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-03-23 DOI:10.1002/jmri.29363

Jiali Li MS, Yuansheng Li MPH, Xin Lin MS, Cheng Lv MS, Xiaoyong Zhang PhD, Jing Chen MD, PhD

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引用次数: 0

摘要

背景：目的：在兔模型中评估肝纤维化发展过程中主动脉血流动力学的变化：动物模型：30只7个月大的雄性家兔接受胆管结扎术（BDL）以诱导LF：场强/序列：胆管结扎术后 14 周内，每两周进行一次四维（4D）血流成像，采用 3.0 T 扫描仪的三维梯度回波：每次 MRI 扫描后，在每个时间点对 2-5 只兔子进行组织病理学检查。病理学家使用 Metavir 量表对 LF 进行分级。两名放射科医生使用专用的后处理软件对 4D 血流进行分析。他们记录了四个主动脉切面（主动脉窦、主动脉弓分叉前后和降主动脉）的 4D 血流参数：线性混合模型；Bonferroni 校正；Pearson 相关系数 (r)；接收者操作特征曲线 (ROC)；Delong 检验。显著性水平设定为 P 结果：BDL 后，主动脉壁剪切应力（WSS）（0.23-0.32 Pa）和能量损失（EL）（0.27-1.55 mW）在第二周显著增加，在第六周达到峰值（WSS：0.35-0.49 Pa，EL：0.57-2.0 mW）。第二平面的相对压力差（RPD）也是如此（第二周：1.67 ± 1.63 mmHg，第六周：2.43 ± 0.63 mmHg）。值得注意的是，第二周平面 2 的相对压力差显示出最高的 ROC 曲线下面积，为 0.998（特异性：1，灵敏度：0.967）。在 BDL 后第二周、第四周和第六周发现 LF，分别为 F2、F3 和 F4 级。平面 2 的 RPD 与 LF 的严重程度相关性最强（r = 0.86）：数据结论：早在 BDL 术后第二周，LF 的发生就会增加主动脉的 WSS、EL 和 RPD：1 技术效率：第 2 阶段。

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Evaluation of Aortic Hemodynamics Using Four-Dimensional Flow of Magnetic Resonance Imaging in Rabbits with Liver Fibrosis

Background

Liver fibrosis (LF) precipitates systemic hemodynamic alterations, however, its impact on the aorta remaining undefined.

Purpose

To assess aorta hemodynamics changes during LF development in a rabbit model.

Study Type

Prospective, experimental.

Animal Model

Thirty 7-month-old male rabbits underwent bile duct ligation (BDL) to induce LF.

Field Strength/Sequence

Biweekly four-dimensional (4D) flow imaging incorporating a 3D gradient-echo at 3.0 T scanner for 14 weeks post-BDL.

Assessment

Histopathological exams for 2–5 rabbits were performed at each time point, following each MRI scan. LF was graded using the Metavir scale by a pathologist. 4D flow was analyzed by two radiologists using dedicated postprocessing software. They recorded 4D flow parameters at four aorta sections (aortic sinus, before and after bifurcation of aortic arch, and descending aorta).

Statistical Tests

The linear mixed model; Bonferroni correction; Pearson correlation coefficient (r); receiver operating characteristic (ROC) curve; Delong test. The level of significance was set at P < 0.05.

Results

Following BDL, the wall shear stress (WSS) (0.23–0.32 Pa), energy loss (EL) (0.27–1.55 mW) of aorta significantly increased at the second week for each plane, peaking at the sixth week (WSS: 0.35–0.49 Pa, EL: 0.57–2.0 mW). So did the relative pressure difference (RPD) (second week: 1.67 ± 1.63 mmHg, sixth week: 2.43 ± 0.63 mmHg) in plane 2. Notably, the RPD in plane 2 at the second week displayed the highest area under ROC curve of 0.998 (specificity: 1, sensitivity: 0.967). LF were found at the second, fourth, and sixth week after BDL, with grade F2, F3, and F4, respectively. The RPD in plane 2 was most strongly correlated with the severity of LF (r = 0.86).