实时连续血糖监测系统在食管癌患者术后肠内营养治疗中的临床应用。

IF 2.1 4区 医学 Q3 NUTRITION & DIETETICS Nutrition in Clinical Practice Pub Date : 2024-08-01 Epub Date: 2024-03-24 DOI:10.1002/ncp.11143
Ranran Zhang, Ying Wu, Rui Xv, Wei Wang, Lei Zhang, Ansheng Wang, Min Li, Wei Jiang, Guoxi Jin, Xiaolei Hu
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引用次数: 0

摘要

背景:肠内营养(EN)支持治疗会增加血糖(BG)异常的风险。本研究旨在评估实时连续血糖监测系统(rt-CGM)在食管癌患者术后接受肠内营养支持治疗期间进行血糖监测的临床价值:方法:研究对象为计划接受术后EN治疗的无糖尿病(DM)食管癌患者。以自我监测血糖值作为参考血糖值,通过平均绝对相对差值(MARD)、相关效率、一致性分析以及 Parkes 和 Clarke 误差网格图评估 rt-CGM 的准确性。最后,采用配对 t 检验比较 EN 日与非 EN 日、慢速日与快速日血糖波动的差异:rt-CGM 系统的总 MARD 值为 13.53%。间质葡萄糖与指尖毛细血管血糖之间存在高度相关性(一致性相关效率 = 0.884 [95% 置信区间,0.874-0.894])。15/15%、20/20%、30/30% 的一致性分析结果分别为 58.51%、84.71% 和 99.65%。Parkes 和 Clarke 误差网格显示,A 区和 B 区的比例分别为 100%和 99.94%。EN 日与非 EN 日、快速日与慢速日的血糖波动较大,差异有统计学意义(P 结论):rt-CGM 系统达到了临床准确性,可作为术后 EN 治疗期间血糖监测的新选择。即使在没有糖尿病的术后人群中,EN 治疗期间的血糖波动幅度仍然很大。
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Clinical application of real-time continuous glucose monitoring system during postoperative enteral nutrition therapy in esophageal cancer patients.

Background: Enteral nutrition (EN) support therapy increases the risk of abnormal blood glucose (BG). The aim of this study is to evaluate the clinical value of a real-time continuous glucose monitoring (rt-CGM) system in BG monitoring during postoperative EN support therapy in patients with esophageal cancer.

Methods: Patients without diabetes mellitus (DM) with esophageal cancer who planned to receive postoperative EN were enrolled. With the self-monitoring of BG value as the reference BG, the accuracy of rt-CGM was evaluated by the mean absolute relative difference (MARD) value, correlation efficient, agreement analysis, and Parkes and Clarke error grid plot. Finally, paired t tests were used to compare the differences in glucose fluctuations between EN and non-EN days and slow and fast days.

Results: The total MARD value of the rt-CGM system was 13.53%. There was a high correlation between interstitial glucose and fingertip capillary BG (consistency correlation efficient = 0.884 [95% confidence interval, 0.874-0.894]). Results of 15/15%, 20/20%, 30/30% agreement analysis were 58.51%, 84.71%, and 99.65%, respectively. The Parkes and Clarke error grid showed that the proportion of the A and B regions were 100% and 99.94%, respectively. The glucose fluctuations on EN days vs non-EN days and on fast days vs slow days were large, and the difference was statistically significant (P < 0.001).

Conclusion: The rt-CGM system achieved clinical accuracy and can be used as a new option for glucose monitoring during postoperative EN therapy. The magnitude of glucose fluctuation during EN therapy remains large, even in the postoperative population without DM.

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来源期刊
CiteScore
6.00
自引率
9.70%
发文量
128
审稿时长
3 months
期刊介绍: NCP is a peer-reviewed, interdisciplinary publication that publishes articles about the scientific basis and clinical application of nutrition and nutrition support. NCP contains comprehensive reviews, clinical research, case observations, and other types of papers written by experts in the field of nutrition and health care practitioners involved in the delivery of specialized nutrition support. This journal is a member of the Committee on Publication Ethics (COPE).
期刊最新文献
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