调节脂蛋白脂肪酶活性的统一模型。

IF 11.4 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-06-01 Epub Date: 2024-03-23 DOI:10.1016/j.tem.2024.02.016
Ren Zhang, Kezhong Zhang
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引用次数: 0

摘要

甘油三酯(TG)组织的分布、储存和利用是能量平衡的基本过程,其调节关键取决于脂蛋白脂肪酶(LPL)。我们回顾了 LPL 活性受血管生成素样蛋白(ANGPTL3、4、8)、脂蛋白(APOA5、APOC3、APOC2)和 cAMP 反应元件结合蛋白 H(CREBH)调控的复杂机制。ANGPTL8 通过形成复合物发挥分子开关的功能,在抑制 LPL 的过程中激活 ANGPTL3,同时使 ANGPTL4 失活。ANGPTL3-4-8 模型综合了上述蛋白在进食/快餐循环期间白脂肪组织(WAT)和氧化组织(心脏和骨骼肌)之间的 TG 分配中的作用。该模型为 LPL 的调控提供了一个统一的视角,为 TG 代谢、代谢性疾病和治疗提供了见解。
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A unified model for regulating lipoprotein lipase activity.

The regulation of triglyceride (TG) tissue distribution, storage, and utilization, a fundamental process of energy homeostasis, critically depends on lipoprotein lipase (LPL). We review the intricate mechanisms by which LPL activity is regulated by angiopoietin-like proteins (ANGPTL3, 4, 8), apolipoproteins (APOA5, APOC3, APOC2), and the cAMP-responsive element-binding protein H (CREBH). ANGPTL8 functions as a molecular switch, through complex formation, activating ANGPTL3 while deactivating ANGPTL4 in their LPL inhibition. The ANGPTL3-4-8 model integrates the roles of the aforementioned proteins in TG partitioning between white adipose tissue (WAT) and oxidative tissues (heart and skeletal muscles) during the feed/fast cycle. This model offers a unified perspective on LPL regulation, providing insights into TG metabolism, metabolic diseases, and therapeutics.

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来源期刊
Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism 医学-内分泌学与代谢
CiteScore
20.10
自引率
0.00%
发文量
98
审稿时长
82 days
期刊介绍: Trends in Endocrinology and Metabolism (TEM) stands as a premier Reviews journal in the realms of metabolism and endocrinology. Our commitment is reflected in the publication of refined, concise, and highly impactful articles that delve into cutting-edge topics, encompassing basic, translational, and clinical aspects. From state-of-the-art treatments for endocrine diseases to groundbreaking developments in molecular biology, TEM provides comprehensive coverage. Explore recent advancements in diabetes, endocrine diseases, obesity, neuroendocrinology, immunometabolism, molecular and cellular biology, and a myriad of other areas through our journal. TEM serves as an invaluable resource for researchers, clinicians, lecturers, teachers, and students. Each monthly issue is anchored by Reviews and Opinion articles, with Reviews meticulously chronicling recent and significant developments, often contributed by leading researchers in specific fields. Opinion articles foster debate and hypotheses. Our shorter pieces include Science & Society, shedding light on issues at the intersection of science, society, and policy; Spotlights, which focus on exciting recent developments in the literature, and single-point hypotheses as Forum articles. We wholeheartedly welcome and encourage responses to previously published TEM content in the form of Letters.
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