Dong Li, Xinyu Wang, Wuxun Chen, Yuan Zou, Jun Wang
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引用次数: 0
摘要
有机薄膜晶体管(OTFT)已被作为一种有前途的传感平台,通过分析其电学参数来检测 DNA 目标分子。OTFT 的源电流/漏电流比(含 DNA 分子和不含 DNA 分子)作为传感器灵敏度已被广泛用于检测和识别 DNA 分子。本文采用不同薄膜厚度的典型有机半导体五碳烯作为 OTFT 的有源层,从而改变了对 DNA 分子的传感器灵敏度。重要的是,该器件的灵敏度与所施加的栅极电压(VG)有显著的相关性,而且随着 VG 的降低,灵敏度有提高的趋势。重要的是,在低 VG 条件下,通过优化沟道厚度,传感器的灵敏度提高了十倍。此外,我们还进行了变温测量,以探索 DNA 分子诱导 OTFT 的电荷机制。我们的研究表明,传感器的灵敏度主要由 OTFT 在线性区域产生的电荷注入过程决定。目前的工作将有助于深入理解基于 OTFT 的生物传感器的工作机制。
Improving the detecting sensitivity of transistor-based DNA sensor by the optimization of channel thicknesses
Organic thin-film transistor (OTFT) has been adopted as a promising sensing platform to detect DNA target molecules by analyzing their electrical parameters. The source/drain current ratio of OTFT (with and without DNA molecules) as the sensor sensitivity have been widely utilized to detect and identify DNA molecules. In this paper, pentacene as a typical organic semiconductor with various thin-film thicknesses have been adopted as the active layer of OTFT that induce to the changeable sensor sensitivity for the DNA molecules. Importantly, the sensitivity of the device shows the remarkable dependence in the applied gate voltages (VG) and an improved trend is observed with the lowering of VG. Importantly, a ten-fold improvement in the sensor sensitivity is achieved by the optimization of channel thicknesses at the low VG condition. Furthermore, the variable-temperature measurements are carried out to explore the charge mechanism of OTFT induced by the DNA molecules. Our studies indicate the sensor sensitivity is mainly determined by the charge-injection process of OTFT arisen in the linear region. Current work will be helpful for deeply understanding the operating mechanism of OTFT-based biosensors.
期刊介绍:
Organic Electronics is a journal whose primary interdisciplinary focus is on materials and phenomena related to organic devices such as light emitting diodes, thin film transistors, photovoltaic cells, sensors, memories, etc.
Papers suitable for publication in this journal cover such topics as photoconductive and electronic properties of organic materials, thin film structures and characterization in the context of organic devices, charge and exciton transport, organic electronic and optoelectronic devices.