一例并发幼年特发性关节炎(JIA)和儿童型多发性硬化症(POMS)的病例--先用secukinumab和富马酸二甲酯治疗,再用ofatumumab治疗

Aleksandra Jartych, A. Jamróz-Wiśniewska, Konrad Rejdak, Weronika Kleszczyńska, Michał Kaczor
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引用次数: 0

摘要

本病例报告旨在强调治疗年轻患者并发幼年特发性关节炎和多发性硬化症的新方法。在一名 22 岁患者的临床病例和文献中,使用 ofatumumab、secukinumab 和富马酸二甲酯都取得了令人鼓舞的结果,这让人们相信,并发自身免疫性疾病患者的生活质量有可能得到改善。然而,对上述疗法的必要性和安全性进行进一步研究至关重要,尤其是在儿科人群中,因为他们在使用未注册的未成年患者治疗方法时往往会遇到困难。此外,还应考虑到合并治疗两种自身免疫性疾病所导致的副作用风险更高。
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A case of concomitant juvenile idiopathic arthritis (JIA) and paediatric-onset multiple sclerosis (POMS) – treatment with secukinumab and dimethyl fumarate followed by ofatumumab
The aim of this case report is to highlight new possible treatment methods for concomitant juvenile idiopathic arthritis and multiple sclerosis in young patients. Promising results of using ofatumumab, secukinumab and dimethyl fumarate, both in the clinical case of a 22-year-old patient and mentioned literature, allows the belief that there is a chance for improving the quality of life of those who suffer from coexisting autoimmune diseases. However, it is crucial to perform further research in terms of the necessity and safety of the mentioned therapies, especially in the paediatric population, among whom there often exists difficulty in using treatment not registered for under-aged patients. Furthermore, the higher risk of side-effects caused by combined treatment of two autoimmune diseases should also be taken into consideration.
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