Mitochondrial involvement in ferroptotic cell death

Ferroptosis is a regulated cell death pathophysiologically associated with the depletion of the antioxidant system due to iron overload, which results in excess lipid peroxidation. Mitochondria are crucial organelles known for their prominent involvement in various cellular metabolic activities and cell death processes. While our understanding of ferroptotic signaling pathways is advancing, further investigation into the intricate relationship between mitochondrial bio-process and this mode of cell death is necessary to identify effective biomedical therapeutic options targeting this organelle. However, the direct involvement of mitochondria in ferroptosis has remained a topic of debate due to the limited availability of concrete information to date. This review aims to elucidate the pathophysiological perspectives of mitochondria during ferroptotic cell death.