非酒精性脂肪肝与组织铁超载之间关系的系统分析:使用多肽疗法的前景广阔领域

I. Torshin, O. Gromova, T. E. Bogacheva
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引用次数: 0

摘要

非酒精性脂肪肝(NAFLD)中的铁超载是一种相当常见的现象,但在临床实践中却很少受到关注。然而,铁超载导致的血色素沉着病("难以消化 "的纳米分散铁氧化物在各种组织中的沉积)会明显加重非酒精性脂肪肝,刺激慢性炎症、胰岛素抵抗和其他器官的血色素沉着病加重。因此,肝细胞发生铁质沉积(铁超载和血色素沉积导致细胞凋亡),从而加速非酒精性脂肪肝向非酒精性脂肪性肝炎(NASH)的转变,随后转变为肝硬化。微量元素缺乏和致病性肠道微生物群会加重铁超载。本文介绍了对这一问题进行系统分析的结果,描述了使用微量营养素和人类胎盘水解物(HPP)进行治疗的前景,这不仅有助于肝组织的再生,还有助于铁平衡的正常化。
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Systematic analysis of the relationship between non-alcoholic fatty liver disease and tissue iron overload: promising areas for the use of polypeptide therapy
Iron overload in non-alcoholic fatty liver disease (NAFLD) is a fairly common phenomenon that receives very little attention in clinical practice. However, iron overload, leading to hemosiderosis (deposition of “indigestible” nanodispersed iron oxides in various tissues) significantly aggravates NAFLD, stimulating increased chronic inflammation, insulin resistance and hemosiderosis of other organs. As a result, ferroptosis of hepatocytes occurs (apoptosis caused by iron overload and hemosiderosis), which accelerates the transformation of non-alcoholic steatosis into non-alcoholic steatohepatitis (NASH) and, subsequently, into liver cirrhosis. Iron overload is aggravated by micronutrient deficiencies and pathogenic intestinal microbiota. The paper presents the results of a systematic analysis of this issue, describes the prospects for therapy using micronutrients and human placenta hydrolysates (HPP), which contribute not only to the regeneration of liver tissue, but also to the normalization of iron homeostasis.
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