医学院收治的对苯二胺中毒(染发剂中毒)病例临床概况回顾性研究

Neha Ahuja, Kanwal Kamboj, Amrita Sinha, Nilam Nigam
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摘要

印度的自杀率很高,其中很大一部分是中毒自杀。染发剂中毒事件日益增多,占中毒事件的很大比例。染发剂中毒的主要毒性成分是对苯二胺(PPD)。本研究通过分析对苯二胺中毒病例的人口统计学特征、临床表现、生化特征、救生措施和死亡率来完成。本研究对 80 个病例进行了分析。血管性水肿、口腔疼痛、深色尿液、口面部水肿是主要的临床特征。TLC计数升高、肝酶(SGPT、SGOT)升高、血清肌酐升高、低钙血症、胆红素升高、低血红蛋白。由于对苯二胺容易获得且价格低廉,如今这种疾病正在蔓延。这种疾病更常见于生活在农村地区的贫困、文盲、已婚年轻女性。积极的治疗和气管切开术可以挽救患者的生命。
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A retrospective study of clinical profile of para-phenylenediamene poisoning (hair dye poisoning) in cases admitted in medical college
India has a high suicide rate and a large proportion of these suicides occur through poisoning. Poisoning by Hair dye has been increasing and constitutes a large proportion of the poisoning cases. The principle toxic constituent of Hair dye poisoning is Paraphenylenediamine (PPD).Present study was done by analyzing the demographic profile, clinical presentation, biochemical profile, life saving interventions and mortality in cases of PPD poisoning. This study was conducted on 80 cases. Angioedema, pain in oral cavity, dark coloured urine, oro-facial edema were main clinical features. Raised TLC count, elevated liver enzymes (sgpt, sgot), elevated serum creatinine, hypocalcemia, elevated bilirubin, low haemoglobin.Paraphenylene diamine poisoning is developing now days due to easy obtainability and low cheap price. It is more common in poor, illiterate, married females of younger age group living in rural areas. Aggressive treatment and Tracheostomy can save life of Patients.
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