一项关于在三级医疗机构管理早产儿视网膜病变患者的研究

Abinashi Sabyasachi Sethy, Santosh Kumar Sethi, Jyotsna Sharma, Mangal Charan Murma, Subhabrata Parida
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引用次数: 0

摘要

早衰性视网膜病变(ROP)是导致青少年视力缺陷的一个重要原因,它为筛查和治疗提供了一个窗口期,使其能够在发展到极端结构之前获得较差的视觉效果。全球有不少于 50,000 名儿童因早衰性视网膜病变(ROP)而视力受损,还有更多的儿童单眼明显受阻或失明。目的:评估奥迪沙地区一家三级新生儿医院对轻度视网膜病变患者的管理及其治疗效果。这是一项基于临床的无误(横断面)研究,于2019年9月至2021年10月在奥迪沙邦卡特塔克市SCBMCH的SNCU和卡特塔克市Sardar Vallabh bhai Patel儿科研究生基金会(SVPPGIP)的SNCU、新生儿重症监护室进行。在近两年的审查期间,共对 310 名儿童进行了早产儿视网膜病变评估,其中 117 名儿童被认为肯定患有早产儿视网膜病变。在我们的复查中,患早产儿猝死症的比例为 37.7%。在我们的研究中,视网膜病变与伴随的危险因素有关,如低胎龄、低出生体重、氧治疗、RDS、苍白、血液粘合和败血症、多胎妊娠、高胆红素血症,其中低出生体重、低胎龄和氧治疗是主要因素。在输注阿瓦斯汀治疗的 31 例病例中,有 26 例在 2 个月的随访中出现复发迹象,只有 5 例在输注贝伐单抗后没有复发迹象。这 5 名患儿在开始治疗 10 天后接受了激光光凝视网膜摘除术,并在 2 个月的随访中出现复发迹象。合理的筛查和 ROP 的诊断可以避免感染发展到更极端的阶段,从而减少视力缺陷的发生。玻璃体内输注血管内皮生长因子可作为治疗合理的视网膜病变病例的基本治疗方法,但还需要进行更多的检查,以确定这些药物的附带效果。
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A study on the management of patients with retinopathy of prematurity in a tertiary care setting
Retinopathy of rashness (ROP) is a critical reason for youth visual deficiency which gives a window period to screening & treatment prior to advancing to an extreme structure having poor visual result. Universally, no less than 50,000 kids are visually impaired because of ROP & an extra obscure number will be outwardly impeded or blind in one eye. To evaluate the administration of patients with Retinopathy of rashness & its result of the treatment applied in a tertiary level neonatal unit in the territory of Odisha. It is a clinic based unmistakable (cross-sectional) study, done from September 2019 to October 2021 done at SNCU of SCBMCH, Cuttack & SNCU, NICU of Sardar Vallabh bhai Patel Postgraduate Foundation of Pediatrics (SVPPGIP), Cuttack, Odisha who qualify the incorporation standards. During the review time of almost 2 years, 310 children were evaluated for ROP in which 117 were viewed as sure for ROP. The frequency of ROP in our review was 37.7%. ROP is viewed as related with the accompanying gamble factors in our review like low gestational age, low birth weight, oxygen treatment, RDS, paleness, blood bonding & septicemia, numerous births, hyperbilirubinemia with low birth weight & low gestational age & oxygen treatment being the main ones. Out of 31 cases treated with Avastin infusion, 26 gave indications of relapse till 2 months follow up & just 5 of them didn't give indications of relapse after infusion Bevacizumab. Those 5 children were treated with retinal removal by LASER photocoagulation following 10 days of beginning treatment, who gave indications of relapse till 2 months follow up. Legitimate screening & the executives of ROP can prompt counteraction of movement of infection to a more extreme stage with poor visual guess, consequently decreasing the weight of experience growing up visual deficiency. Intra vitreal hostile to VEGF infusion can be utilized as essential treatment for treatment justified ROP cases however more examination is expected to figure out the drawn out incidental effect profile of these medications.
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