高同型半胱氨酸血症是慢性肾病患者出现血管并发症的一个风险因素

I.A. Paliienko, O.V. Karpenko, I. Krasiuk, A.D. Kravchuk, Y.V. Mykolaienko, O.A. Rudenko
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引用次数: 0

摘要

高同型半胱氨酸血症被认为是包括血栓形成在内的多种疾病的危险因素。慢性肾脏病患者通常会出现动脉或静脉血栓形成等血管并发症,因此将血液中的同型半胱氨酸水平作为血栓性疾病的预测指标非常重要。高同型半胱氨酸血症的原因可能是基因突变、同型半胱氨酸代谢酶缺乏、叶酸和维生素 B12 缺乏,其次是影响蛋氨酸代谢的维生素 B6 缺乏。鉴于高同型半胱氨酸血症是肾脏疾病患者心血管事件的预测因子,我们认为,同型半胱氨酸增高的多因素性质要求进一步研究其在慢性肾脏疾病中发病机制的某些环节,并制定有针对性的治疗干预措施。
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Hyperhomocysteinemia is a risk factor for vascular complications in patients with chronic kidney disease
Hyperhomocysteinemia is considered a risk factor for many diseases, including thrombosis. Patients with chronic kidney disease often have vascular complications in the form of arterial or venous thrombosis, and it is important to consider the blood homocysteine level as a predictor of thrombophilia. The causes of hyperhomocysteinemia can be both genetic mutations and deficiency of homocysteine metabolism enzymes, as well as deficiency of folic acid, vitamin B12 and, to a lesser extent, deficiency of vitamin B6, which affects methionine metabolism. Given the role of hyperhomocysteinemia as a predictor of cardiovascular events in patients with kidney diseases, in our opinion, the multifactorial nature of increased homocysteine requires further research into some links of its pathogenesis in chronic kidney disease and the development of targeted therapeutic interventions.
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