Pub Date : 2024-06-16DOI: 10.22141/2307-1257.13.2.2024.452
L.D. Denova
Background. The purpose of this study was to investigate urinary uromodulin (uUMOD) excretion, reactivity of the autonomic nervous system and impaired renal blood circulation in patients with predialysis chronic kidney disease (CKD), the effect of antioxidant therapy on these parameters. Materials and methods. Ninety-one patients with CKD stage 1–5 whose average age was 47.00 ± 12.12 years took part in the ROLUNT (UROmoduLin UbiquinoNe GlutaThione) study. Thirty (32.97 %) men and 61 (67.03 %) women were divided into two groups, which were representative in terms of age and gender composition: group 1 (n = 46) — patients with CKD stage 1–5 who had a Charlson comorbidity index ≤ 2, group 2 (n = 45) — patients with CKD stage 1–5 who had a Charlson comorbidity index ≥ 3. Both groups were divided into subgroups A and B. Subgroups A included patients with impaired vegetative status, subgroups B — those without impaired vegetative status. The first A and second B subgroups took glutathione 100 mg twice a day with food for 3 months, the first B and second A subgroups took ubiquinone 100 mg once a day with food for 3 months. Results. The results of the paired t-test showed that there is a significant difference between the indicators at baseline and at the end of the study. The Pearson correlation results showed that in the group 1 (subgroup A), there is a significant average positive relationship between uUMOD and estimated glomerular filtration rate (r(21) = 0.418, p = 0.047); in the group 1 (subgroup B), there is a significant large positive relationship between uUMOD and Hb indicators (r(21) = 0.513, p = 0.012); a significant very small negative relationship between uUMOD and albumin-creatinine ratio (r(21) = 0.441, p = 0.035); in the group 2 (subgroup A), there is a significant very small negative relationship between uUMOD indicators and Kérdö index (r(20) = 0.427, p = 0.048); in the group 2 (subgroup B), there is a significant very small negative relationship between the uUMOD indicators and Yu.M. Chernov’s questionnaire (r(21) = 0.421, p = 0.045). Conclusions. Antioxidant therapy with glutathione and ubiquinone significantly affects the examination parameters in patients with CKD. Considering the safety and effectiveness of antioxidant therapy, we suggest including it in the treatment protocols for patients with CKD. Further research is recommended to develop a standard protocol.
研究背景本研究旨在调查透析前慢性肾脏病（CKD）患者尿液中尿嘧啶（uUMOD）的排泄量、自主神经系统的反应性和肾血液循环受损的情况，以及抗氧化疗法对这些参数的影响。材料和方法91 名平均年龄为 47.00 ± 12.12 岁的 1-5 期 CKD 患者参加了 ROLUNT（UROmoduLin UbiquinoNe GlutaThione）研究。30名男性（32.97%）和61名女性（67.03%）被分为两组，这两组在年龄和性别构成方面具有代表性：第1组（n = 46）--查尔森合并症指数≤2的CKD 1-5期患者，第2组（n = 45）--查尔森合并症指数≥3的CKD 1-5期患者。两组均分为 A 和 B 亚组，A 亚组包括植物状态受损的患者，B 亚组--无植物状态受损的患者。第一A和第二B亚组服用谷胱甘肽100毫克，每天2次，连服3个月；第一B和第二A亚组服用泛醌100毫克，每天1次，连服3个月。结果配对 t 检验结果显示，基线和研究结束时的各项指标之间存在显著差异。皮尔逊相关结果显示，在第1组（A亚组）中，uUMOD与估计肾小球滤过率之间存在显著的平均正相关关系（r（21）= 0.418，P = 0.047）；在第1组（B亚组）中，uUMOD与Hb指标之间存在显著的较大正相关关系（r（21）= 0.513，P = 0.012）；uUMOD与白蛋白-肌酐比值之间存在显著的极小负相关关系（r（21）= 0.441, p = 0.035）；在第 2 组（A 子组）中，uUMOD 指标与 Kérdö 指数（r(20) = 0.427, p = 0.048）之间存在显著的极小负相关关系；在第 2 组（B 子组）中，uUMOD 指标与 Yu.M. Chernov 问卷（r(21) = 0.421, p = 0.045）之间存在显著的极小负相关关系。结论谷胱甘肽和泛醌的抗氧化治疗对慢性肾脏病患者的检查指标有显著影响。考虑到抗氧化疗法的安全性和有效性，我们建议将其纳入慢性肾脏病患者的治疗方案中。建议开展进一步研究，以制定标准方案。
{"title":"Evaluation of the index of resistance and excretion of uromodulin in patients with predialysis CKD, taking into account the index of comorbidity","authors":"L.D. Denova","doi":"10.22141/2307-1257.13.2.2024.452","DOIUrl":"https://doi.org/10.22141/2307-1257.13.2.2024.452","url":null,"abstract":"Background. The purpose of this study was to investigate urinary uromodulin (uUMOD) excretion, reactivity of the autonomic nervous system and impaired renal blood circulation in patients with predialysis chronic kidney disease (CKD), the effect of antioxidant therapy on these parameters. Materials and methods. Ninety-one patients with CKD stage 1–5 whose average age was 47.00 ± 12.12 years took part in the ROLUNT (UROmoduLin UbiquinoNe GlutaThione) study. Thirty (32.97 %) men and 61 (67.03 %) women were divided into two groups, which were representative in terms of age and gender composition: group 1 (n = 46) — patients with CKD stage 1–5 who had a Charlson comorbidity index ≤ 2, group 2 (n = 45) — patients with CKD stage 1–5 who had a Charlson comorbidity index ≥ 3. Both groups were divided into subgroups A and B. Subgroups A included patients with impaired vegetative status, subgroups B — those without impaired vegetative status. The first A and second B subgroups took glutathione 100 mg twice a day with food for 3 months, the first B and second A subgroups took ubiquinone 100 mg once a day with food for 3 months. Results. The results of the paired t-test showed that there is a significant difference between the indicators at baseline and at the end of the study. The Pearson correlation results showed that in the group 1 (subgroup A), there is a significant average positive relationship between uUMOD and estimated glomerular filtration rate (r(21) = 0.418, p = 0.047); in the group 1 (subgroup B), there is a significant large positive relationship between uUMOD and Hb indicators (r(21) = 0.513, p = 0.012); a significant very small negative relationship between uUMOD and albumin-creatinine ratio (r(21) = 0.441, p = 0.035); in the group 2 (subgroup A), there is a significant very small negative relationship between uUMOD indicators and Kérdö index (r(20) = 0.427, p = 0.048); in the group 2 (subgroup B), there is a significant very small negative relationship between the uUMOD indicators and Yu.M. Chernov’s questionnaire (r(21) = 0.421, p = 0.045). Conclusions. Antioxidant therapy with glutathione and ubiquinone significantly affects the examination parameters in patients with CKD. Considering the safety and effectiveness of antioxidant therapy, we suggest including it in the treatment protocols for patients with CKD. Further research is recommended to develop a standard protocol.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-16DOI: 10.22141/2307-1257.13.2.2024.457
Parth B. Solanki
Renal transplantation is the preferred treatment for end-stage renal disease, with vascular complications being a significant cause of graft dysfunction. Although many surgical methods are used to ensure the most effective possible vascular anastomosis, autologous saphenous vein grafting remains a less explored approach to renal transplantation. Chronic kidney disease often presents with complications related to impaired renal perfusion, necessitating interventions to improve blood flow to the kidneys. Herein, we present a case report detailing the utilization of autologous saphenous grafting to establish an anastomosis between the renal vein and external iliac vein in a patient with сhronic kidney disease with maintenance hemodialysis twice a week. This case report indicates the potential and prospective advantages of using autologous saphenous grafting for intricate renal vein reconstructions in patients with chronic kidney disease.
{"title":"Autologous vein graft in living donor kidney transplant (case report)","authors":"Parth B. Solanki","doi":"10.22141/2307-1257.13.2.2024.457","DOIUrl":"https://doi.org/10.22141/2307-1257.13.2.2024.457","url":null,"abstract":"Renal transplantation is the preferred treatment for end-stage renal disease, with vascular complications being a significant cause of graft dysfunction. Although many surgical methods are used to ensure the most effective possible vascular anastomosis, autologous saphenous vein grafting remains a less explored approach to renal transplantation. Chronic kidney disease often presents with complications related to impaired renal perfusion, necessitating interventions to improve blood flow to the kidneys. Herein, we present a case report detailing the utilization of autologous saphenous grafting to establish an anastomosis between the renal vein and external iliac vein in a patient with сhronic kidney disease with maintenance hemodialysis twice a week. This case report indicates the potential and prospective advantages of using autologous saphenous grafting for intricate renal vein reconstructions in patients with chronic kidney disease.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"1 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.22141/2307-1257.13.1.2024.441
R. Zograbian, O. Voroniak
The number of patients with end-stage renal disease in Ukraine, as in the whole world, increases. Kidney transplantation remains the most effective method of treatment for such patients. After 1933, when in Ukraine the world’s first kidney transplantation was performed, the number of there surgeries remained insignificant (up to 130 operations per year). In 2018–2020, the reform of transplantation in Ukraine began due to the change of some laws. And as a result, the number of such operations is growing every year. Control over the transplantation process is carried out by a newly created body of the Ministry of Health of Ukraine, the Ukrainian Transplant Coordination Center. New transplant centers are being created, immunological support of transplant couples is being improved using polymerase chain reaction, flow cytometers and solid-phase methods due to HLA typing of the donor and recipient according to A, B, C, DR, DQ, DP loci, detection of anti-HLA antibodies, allele-specific anti-HLA antibodies using single antigen bead assay. Examinations of patients are carried out at the pre-transplantation stage and as part of monitoring after transplantation. Given the military actions, the lack of aviation and the long time of getting to the clinic, it became possible to preserve organs by methods of hypothermic or nomothermic perfusion. The number of organ transplantations is increasing. In 2023, several successful simultaneous heart and kidney, kidney and pancreas transplantations were performed. The problems of overcoming tissue incompatibility, choosing the optimal immunosuppressive therapy regimen for a given patient, training of nephrologists, wider and more effective use of perfusion machines, new protocols of immunosuppressive therapy, studying the peculiarities of kidney transplantation from marginal donors (the number of which in Ukraine prevails), kidney transplantation in highly sensitized recipients are still actual in Ukraine. The cooperation with our European and American colleagues is very important to improve the long-term results of such operations.
{"title":"New approaches to kidney transplantation in Ukraine","authors":"R. Zograbian, O. Voroniak","doi":"10.22141/2307-1257.13.1.2024.441","DOIUrl":"https://doi.org/10.22141/2307-1257.13.1.2024.441","url":null,"abstract":"The number of patients with end-stage renal disease in Ukraine, as in the whole world, increases. Kidney transplantation remains the most effective method of treatment for such patients. After 1933, when in Ukraine the world’s first kidney transplantation was performed, the number of there surgeries remained insignificant (up to 130 operations per year). In 2018–2020, the reform of transplantation in Ukraine began due to the change of some laws. And as a result, the number of such operations is growing every year. Control over the transplantation process is carried out by a newly created body of the Ministry of Health of Ukraine, the Ukrainian Transplant Coordination Center. New transplant centers are being created, immunological support of transplant couples is being improved using polymerase chain reaction, flow cytometers and solid-phase methods due to HLA typing of the donor and recipient according to A, B, C, DR, DQ, DP loci, detection of anti-HLA antibodies, allele-specific anti-HLA antibodies using single antigen bead assay. Examinations of patients are carried out at the pre-transplantation stage and as part of monitoring after transplantation. Given the military actions, the lack of aviation and the long time of getting to the clinic, it became possible to preserve organs by methods of hypothermic or nomothermic perfusion. The number of organ transplantations is increasing. In 2023, several successful simultaneous heart and kidney, kidney and pancreas transplantations were performed. The problems of overcoming tissue incompatibility, choosing the optimal immunosuppressive therapy regimen for a given patient, training of nephrologists, wider and more effective use of perfusion machines, new protocols of immunosuppressive therapy, studying the peculiarities of kidney transplantation from marginal donors (the number of which in Ukraine prevails), kidney transplantation in highly sensitized recipients are still actual in Ukraine. The cooperation with our European and American colleagues is very important to improve the long-term results of such operations.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140244447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.22141/2307-1257.13.1.2024.438
MD Alfonsas Vainoras, G. Nevoit, A. Stankuviene, Jaru š evi č ius, R. McCraty, M. Landauskas, M. Potyazhenko, I. A. Bumblyte, G. J. Š. E. Č. ius, R. McCrаty
Background. The pandemic of noncommunicable chronic diseases and the high prevalence of combined damage to the cardiovascular system and kidneys determine the relevance of continuing scientific research to solve these medical problems. Therefore, the aim of this study was to compare the influence of the Earth’s electromagnetic field on the occurrence of episodes of kidney disease and myocardial infarction in order to search for new pathogenetic components of cardiorenal syndrome and deepen fundamental knowledge. According to the Lithuanian magnetometer GCI003, a number of studies in 2014–2018 found that changes in the Earth’s electromagnetic field may play an important role in the pathogenesis of cardiovascular diseases as well as their incidence. Since the functioning of the cardiovascular system and kidneys are closely connected through the metabolic processes of the cardiorenal metabolic axis, this study tested the hypothesis that changes in the Earth’s electromagnetic field may also affect the pathogenesis of kidney disease as the changes of local magnetic field have been shown to influence the functioning of the cardiovascular system. Materials and methods. This was a search retrospective study on the relationship between the influence of local Schumann resonances and the occurrence of hospitalizations in 1340 patients with kidney disease. It also examined the relationship between local Schumann resonances and heart attacks in patients admitted to the University Hospital of the Lithuanian University of Health Sciences (703 patients). Mean power of local magnetic field fluctuations in Lithuania was measured in pT2 s2 in five different frequency ranges, which overlaps the Schumann resonance and electroencephalogram’s frequency ranges: SDelta (0–3.5 Hz), STheta (3.5–7 Hz), SAlpha (7–15 Hz), SBeta (15–32 Hz), SGamma (32–66 Hz). The data of hospitalizations to the Nephrology Department of University Hospital and the dynamics of Schumann resonances were analyzed from January 1, 2021 to December 31, 2021. The data of hospitalizations for myocardial infarction to the Cardiology Department of University Hospital and the dynamics of Schumann resonances were studied from January 1, 2016 to December 31, 2016. Results. It was found that changes in the strength of the Earth’s local magnetic field in 2016 and 2021 were comparable and corresponded to the characteristic annual dynamics of the Earth’s local electromagnetic fields. This made it possible to conduct a comparative analysis of annual correlation graphs and establish general trends in the dynamics of indicators and graphical similarities. It confirmed the presence of a general dependence of reactions to the external electromagnetic field of the Earth in female and male patients both with nephrological pathology and myocardial infarction. In nephrological patients of both sexes, all correlation coefficients in all ranges of Schumann resonances were positive. The only negative correlation coefficie
{"title":"The search for new pathogenesis of cardiorenal syndrome: the effect of local Schumann resonance on the occurrence of episodes of kidney disease and myocardial infarction","authors":"MD Alfonsas Vainoras, G. Nevoit, A. Stankuviene, Jaru š evi č ius, R. McCraty, M. Landauskas, M. Potyazhenko, I. A. Bumblyte, G. J. Š. E. Č. ius, R. McCrаty","doi":"10.22141/2307-1257.13.1.2024.438","DOIUrl":"https://doi.org/10.22141/2307-1257.13.1.2024.438","url":null,"abstract":"Background. The pandemic of noncommunicable chronic diseases and the high prevalence of combined damage to the cardiovascular system and kidneys determine the relevance of continuing scientific research to solve these medical problems. Therefore, the aim of this study was to compare the influence of the Earth’s electromagnetic field on the occurrence of episodes of kidney disease and myocardial infarction in order to search for new pathogenetic components of cardiorenal syndrome and deepen fundamental knowledge. According to the Lithuanian magnetometer GCI003, a number of studies in 2014–2018 found that changes in the Earth’s electromagnetic field may play an important role in the pathogenesis of cardiovascular diseases as well as their incidence. Since the functioning of the cardiovascular system and kidneys are closely connected through the metabolic processes of the cardiorenal metabolic axis, this study tested the hypothesis that changes in the Earth’s electromagnetic field may also affect the pathogenesis of kidney disease as the changes of local magnetic field have been shown to influence the functioning of the cardiovascular system. Materials and methods. This was a search retrospective study on the relationship between the influence of local Schumann resonances and the occurrence of hospitalizations in 1340 patients with kidney disease. It also examined the relationship between local Schumann resonances and heart attacks in patients admitted to the University Hospital of the Lithuanian University of Health Sciences (703 patients). Mean power of local magnetic field fluctuations in Lithuania was measured in pT2 s2 in five different frequency ranges, which overlaps the Schumann resonance and electroencephalogram’s frequency ranges: SDelta (0–3.5 Hz), STheta (3.5–7 Hz), SAlpha (7–15 Hz), SBeta (15–32 Hz), SGamma (32–66 Hz). The data of hospitalizations to the Nephrology Department of University Hospital and the dynamics of Schumann resonances were analyzed from January 1, 2021 to December 31, 2021. The data of hospitalizations for myocardial infarction to the Cardiology Department of University Hospital and the dynamics of Schumann resonances were studied from January 1, 2016 to December 31, 2016. Results. It was found that changes in the strength of the Earth’s local magnetic field in 2016 and 2021 were comparable and corresponded to the characteristic annual dynamics of the Earth’s local electromagnetic fields. This made it possible to conduct a comparative analysis of annual correlation graphs and establish general trends in the dynamics of indicators and graphical similarities. It confirmed the presence of a general dependence of reactions to the external electromagnetic field of the Earth in female and male patients both with nephrological pathology and myocardial infarction. In nephrological patients of both sexes, all correlation coefficients in all ranges of Schumann resonances were positive. The only negative correlation coefficie","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"18 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140243416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.22141/2307-1257.13.1.2024.439
L.D. Denova, D. Ivanov
Background. Impaired kidney function has a negative effect on the body’s acid-base status (ABS). However, a violation of ABS can worsen the course of chronic kidney disease (CKD). Therefore, during the examination and treatment of patients with CKD, it is necessary to take into account the ABS. The purpose of the study: to conduct a retrospective analysis of the dynamics of ABS indicators in patients with stage 1–5 CKD who sought outpatient medical care in a medical institution in Kyiv. Materials and methods. A retrospective, randomized, cohort study was performed of 53 medical records of patients (form 025/o) who sought outpatient medical care at the Professor Dmytro Ivanov Nephrological Clinic LLC with a diagnosis of stage 1–5 CKD from February 2022 to February 2023. Participants were examined for ABS indicators three times. They were divided into 2 groups: group 1 (n = 31) — stage 1–3 CKD and group 2 (n = 22) — stage 4–5 CKD. An analysis of ABS indicators was carried out in dynamics. Results. Results of multiple linear regression for patients with stage 1–5 CKD (n = 53) showed that there was a strong significant effect between potassium (K+) and glomerular filtration rate (GFR) (F(1, 13) = 10.59, p = 0.006, R2 = 0.45, R2 adj = 0.41). The results of multiple linear regression of indicators in patients with stage 1–3 CKD (group 1) demonstrated a weak insignificant influence between lactate and GFR (F(1, 15) = 1.11, p = 0.310, R2 = 0.07, R2 adj = 0.01). The results of multiple linear regression of indicators in patients with stage 4–5 CKD (group 2) showed that there is a very strong combined insignificant influence between the hydrogen index, partial pressure of carbon dioxide, partial pressure of oxygen, bicarbonate concentration, base excess of extracellular fluid, K+, total carbon dioxide, anion gap with K concentration included in the equation, base excess, lactate and GFR (F(10, –3) = 0.3, p = 58.099, R2 = –65.23, R2 adj = 155.53). Conclusions. When studying ABS in patients with stage 1–5 CKD, a correlation was found between K+ and GFR using the multiple linear regression tool. In the first group, the relationship between lactate and GFR, in the second one, all predictors had a relationship with GFR.
{"title":"Retrospective study of acid-base disturbances in patients with chronic kidney disease","authors":"L.D. Denova, D. Ivanov","doi":"10.22141/2307-1257.13.1.2024.439","DOIUrl":"https://doi.org/10.22141/2307-1257.13.1.2024.439","url":null,"abstract":"Background. Impaired kidney function has a negative effect on the body’s acid-base status (ABS). However, a violation of ABS can worsen the course of chronic kidney disease (CKD). Therefore, during the examination and treatment of patients with CKD, it is necessary to take into account the ABS. The purpose of the study: to conduct a retrospective analysis of the dynamics of ABS indicators in patients with stage 1–5 CKD who sought outpatient medical care in a medical institution in Kyiv. Materials and methods. A retrospective, randomized, cohort study was performed of 53 medical records of patients (form 025/o) who sought outpatient medical care at the Professor Dmytro Ivanov Nephrological Clinic LLC with a diagnosis of stage 1–5 CKD from February 2022 to February 2023. Participants were examined for ABS indicators three times. They were divided into 2 groups: group 1 (n = 31) — stage 1–3 CKD and group 2 (n = 22) — stage 4–5 CKD. An analysis of ABS indicators was carried out in dynamics. Results. Results of multiple linear regression for patients with stage 1–5 CKD (n = 53) showed that there was a strong significant effect between potassium (K+) and glomerular filtration rate (GFR) (F(1, 13) = 10.59, p = 0.006, R2 = 0.45, R2 adj = 0.41). The results of multiple linear regression of indicators in patients with stage 1–3 CKD (group 1) demonstrated a weak insignificant influence between lactate and GFR (F(1, 15) = 1.11, p = 0.310, R2 = 0.07, R2 adj = 0.01). The results of multiple linear regression of indicators in patients with stage 4–5 CKD (group 2) showed that there is a very strong combined insignificant influence between the hydrogen index, partial pressure of carbon dioxide, partial pressure of oxygen, bicarbonate concentration, base excess of extracellular fluid, K+, total carbon dioxide, anion gap with K concentration included in the equation, base excess, lactate and GFR (F(10, –3) = 0.3, p = 58.099, R2 = –65.23, R2 adj = 155.53). Conclusions. When studying ABS in patients with stage 1–5 CKD, a correlation was found between K+ and GFR using the multiple linear regression tool. In the first group, the relationship between lactate and GFR, in the second one, all predictors had a relationship with GFR.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"10 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140243854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.22141/2307-1257.13.1.2024.445
PhD Yekhalov Vasyl Vitaliiovych, O. Kravets, V. Yekhalov, V. Gorbuntsov, D. Krishtafor
Recently discovered specific markers open up new possibilities for the diagnosis of acute kidney injury (AKI) in burn disease in order to optimize the treatment of such patients. Early diagnosis with the involvement of biomarkers prevents the sudden death of burn patients and allows predicting the course of the pathological condition. There are several characteristics that an “ideal” AKI biomarker should conform to: being non-invasive, locally specific, highly sensitive, being a stable molecule at different temperatures and pH values, having the ability to rapidly increase in response to kidney injury (quantify it), remaining at high levels during the episode and decreasing during the recovery period. There is a difference between the biomarkers that can be freely filtered in the glomerulus, so any increase in their plasma concentration (due to damage to other renal tissues) can lead to a high concentration of indicators in the urine (loss of specificity), and high-molecular-weight markers that are not freely filtered and therefore are more specific when measured in urine. Renal function in burn patients is usually determined by blood and urine tests, as biopsy can cause iatrogenic damage and is not commonly used in this cohort. After the onset of AKI, the level of biomarkers remains elevated for a certain period. None of the described indicators is monospecific for AKI; this makes estimating the time of AKI quite difficult. It has been proven that the combination of three biomarkers at two different time points in adults and the combination of two indicators at two time intervals in children allows to increase the reliability of determining AKI up to 0.78
最近发现的特异性标志物为诊断烧伤疾病中的急性肾损伤（AKI）提供了新的可能性，以便优化对此类患者的治疗。利用生物标记物进行早期诊断可以防止烧伤病人猝死，并能预测病理过程。理想的 "AKI 生物标志物应符合以下几个特征：非侵入性、局部特异性、高灵敏度、在不同温度和 pH 值下是稳定的分子、能够迅速增加对肾损伤的反应（量化）、在发作期间保持高水平，并在恢复期间降低。在肾小球中可自由过滤的生物标志物与高分子量标志物之间存在差异，前者可自由过滤，因此其血浆浓度的任何增加（由于其他肾组织受损）都会导致尿液中指标的高浓度（失去特异性），而后者不能自由过滤，因此在尿液中测量时更具特异性。烧伤患者的肾功能通常通过血液和尿液检查来确定，因为活组织检查会造成先天性损伤，因此在这类患者中并不常用。发生 AKI 后，生物标志物的水平会在一段时间内持续升高。所描述的指标都不是针对 AKI 的单一特异性指标；这使得估计 AKI 的时间变得相当困难。事实证明，在成人中将三个生物标志物在两个不同的时间点结合起来，在儿童中将两个指标在两个时间间隔结合起来，可以将确定 AKI 的可靠性提高到 0.78。
{"title":"Kidney damage in burn disease. Part 2. Biochemical markers (literature review)","authors":"PhD Yekhalov Vasyl Vitaliiovych, O. Kravets, V. Yekhalov, V. Gorbuntsov, D. Krishtafor","doi":"10.22141/2307-1257.13.1.2024.445","DOIUrl":"https://doi.org/10.22141/2307-1257.13.1.2024.445","url":null,"abstract":"Recently discovered specific markers open up new possibilities for the diagnosis of acute kidney injury (AKI) in burn disease in order to optimize the treatment of such patients. Early diagnosis with the involvement of biomarkers prevents the sudden death of burn patients and allows predicting the course of the pathological condition. There are several characteristics that an “ideal” AKI biomarker should conform to: being non-invasive, locally specific, highly sensitive, being a stable molecule at different temperatures and pH values, having the ability to rapidly increase in response to kidney injury (quantify it), remaining at high levels during the episode and decreasing during the recovery period. There is a difference between the biomarkers that can be freely filtered in the glomerulus, so any increase in their plasma concentration (due to damage to other renal tissues) can lead to a high concentration of indicators in the urine (loss of specificity), and high-molecular-weight markers that are not freely filtered and therefore are more specific when measured in urine. Renal function in burn patients is usually determined by blood and urine tests, as biopsy can cause iatrogenic damage and is not commonly used in this cohort. After the onset of AKI, the level of biomarkers remains elevated for a certain period. None of the described indicators is monospecific for AKI; this makes estimating the time of AKI quite difficult. It has been proven that the combination of three biomarkers at two different time points in adults and the combination of two indicators at two time intervals in children allows to increase the reliability of determining AKI up to 0.78","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"18 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140244373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.22141/2307-1257.13.1.2024.443
I.A. Paliienko, O.V. Karpenko, I. Krasiuk, A.D. Kravchuk, Y.V. Mykolaienko, O.A. Rudenko
Hyperhomocysteinemia is considered a risk factor for many diseases, including thrombosis. Patients with chronic kidney disease often have vascular complications in the form of arterial or venous thrombosis, and it is important to consider the blood homocysteine level as a predictor of thrombophilia. The causes of hyperhomocysteinemia can be both genetic mutations and deficiency of homocysteine metabolism enzymes, as well as deficiency of folic acid, vitamin B12 and, to a lesser extent, deficiency of vitamin B6, which affects methionine metabolism. Given the role of hyperhomocysteinemia as a predictor of cardiovascular events in patients with kidney diseases, in our opinion, the multifactorial nature of increased homocysteine requires further research into some links of its pathogenesis in chronic kidney disease and the development of targeted therapeutic interventions.
{"title":"Hyperhomocysteinemia is a risk factor for vascular complications in patients with chronic kidney disease","authors":"I.A. Paliienko, O.V. Karpenko, I. Krasiuk, A.D. Kravchuk, Y.V. Mykolaienko, O.A. Rudenko","doi":"10.22141/2307-1257.13.1.2024.443","DOIUrl":"https://doi.org/10.22141/2307-1257.13.1.2024.443","url":null,"abstract":"Hyperhomocysteinemia is considered a risk factor for many diseases, including thrombosis. Patients with chronic kidney disease often have vascular complications in the form of arterial or venous thrombosis, and it is important to consider the blood homocysteine level as a predictor of thrombophilia. The causes of hyperhomocysteinemia can be both genetic mutations and deficiency of homocysteine metabolism enzymes, as well as deficiency of folic acid, vitamin B12 and, to a lesser extent, deficiency of vitamin B6, which affects methionine metabolism. Given the role of hyperhomocysteinemia as a predictor of cardiovascular events in patients with kidney diseases, in our opinion, the multifactorial nature of increased homocysteine requires further research into some links of its pathogenesis in chronic kidney disease and the development of targeted therapeutic interventions.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"1 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140244606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.22141/2307-1257.13.1.2024.446
No Authors
No abstract
无摘要
{"title":"Selected abstracts from the World Kidney Day conference on March 11, 2024","authors":"No Authors","doi":"10.22141/2307-1257.13.1.2024.446","DOIUrl":"https://doi.org/10.22141/2307-1257.13.1.2024.446","url":null,"abstract":"No abstract","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"71 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140242253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.22141/2307-1257.13.1.2024.444
I. Krasiuk, L.D. Denova, O.V. Karpenko
Cystic diseases of the kidneys are a fairly common pathology, which has a negative impact on the course of underlying disease affecting the kidneys, or even being the primary renal pathology. The purpose of this review is to analyze the latest literature data on the etiology, pathogenesis, and diagnosis of cystic kidney diseases. This article highlights some aspects of the pathogenesis, diagnosis, and treatment of cystic kidney diseases in order to deepen knowledge about this pathology. Important nuances of ultrasound diagnosis of cystic kidney diseases are discussed. Modern equipment allows diagnosing almost all variants of cystic kidney disease. Training in ultrasound examination or at least knowledge of sonographic interpretation should be part of training in nephrology.
{"title":"Modern paradigm in the diagnosis of cystic diseases of the kidneys","authors":"I. Krasiuk, L.D. Denova, O.V. Karpenko","doi":"10.22141/2307-1257.13.1.2024.444","DOIUrl":"https://doi.org/10.22141/2307-1257.13.1.2024.444","url":null,"abstract":"Cystic diseases of the kidneys are a fairly common pathology, which has a negative impact on the course of underlying disease affecting the kidneys, or even being the primary renal pathology. The purpose of this review is to analyze the latest literature data on the etiology, pathogenesis, and diagnosis of cystic kidney diseases. This article highlights some aspects of the pathogenesis, diagnosis, and treatment of cystic kidney diseases in order to deepen knowledge about this pathology. Important nuances of ultrasound diagnosis of cystic kidney diseases are discussed. Modern equipment allows diagnosing almost all variants of cystic kidney disease. Training in ultrasound examination or at least knowledge of sonographic interpretation should be part of training in nephrology.","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"12 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140243430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-14DOI: 10.22141/2307-1257.13.1.2024.447
No Authors
No abstract
无摘要
{"title":"COURSE PROGRAM “WKD in Ukraine: Advancing equitable access to pediatric nephrology care and optimal medication practice”","authors":"No Authors","doi":"10.22141/2307-1257.13.1.2024.447","DOIUrl":"https://doi.org/10.22141/2307-1257.13.1.2024.447","url":null,"abstract":"No abstract","PeriodicalId":17874,"journal":{"name":"KIDNEYS","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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