肝病细胞疗法：从肝细胞移植到生物人工肝

IF 4.7 3区工程技术 Q2 ENGINEERING, BIOMEDICAL Current Opinion in Biomedical Engineering Pub Date : 2024-03-12 DOI:10.1016/j.cobme.2024.100530

Xiang Yuan , Zhen Sun , Jingqi Wu , Lijian Hui , Ludi Zhang

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引用次数: 0

摘要

对于肝功能衰竭和遗传性肝病患者来说，肝细胞疗法是肝脏移植手术的一种很有前途的替代疗法。然而，由于人类肝细胞的稀缺，其临床应用受到了限制。在此，我们回顾了生成具有成熟表型和肝脏再填充能力的功能性人类肝细胞的策略，并强调了其在肝细胞移植和生物人工肝移植中的潜在临床应用。我们总结了改善肝细胞移植的新给药方法，如贴片移植和异位移植，并讨论了潜在的未来发展方向。

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Cell therapy for liver diseases: From hepatocyte transplantation to bioartificial livers

Liver cell therapy presents a promising alternative to liver transplantation for patients with liver failure and hereditary liver diseases. However, its clinical implementation is limited largely due to the scarcity of human hepatocytes. Here, we review strategies to generate functional human hepatocytes with a mature phenotype and liver repopulation capability and highlight their potential clinical applications in hepatocyte transplantation and bioartificial liver transplantation. We summarize new delivery methods to improve hepatocyte engraftment, such as patch grafting and ectopic transplantation, and discuss potential future directions.

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