对患有冯-威廉氏病的兄弟进行侵入性牙科治疗的管理

IF 0.6 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Pediatric Dental Journal Pub Date : 2024-03-16 DOI:10.1016/j.pdj.2024.03.002

Tamami Kadota, Yusuke Mikasa, Makoto Okuda, Misato Takagi, Katsuaki Kuremoto, Katsuhiko Masuda, Rena Okawa, Kazuhiko Nakano

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摘要

背景冯-威廉氏病（VWD）是一种由冯-威廉因子蛋白异常引起的出血性疾病。病例介绍两兄弟被确诊为冯-威廉氏病，哥哥接受龋齿治疗，弟弟接受基牙拔除术。为了控制术中出血和术后止血，哥哥在牙科治疗前一天静脉注射了血浆提取物/因子 VIII 浓缩液，而弟弟则在术前注射了去氨加压素，因为发现这种方法很有效。

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Management of invasive dental treatment for brothers with von Willebrand disease

Background

von Willebrand disease (VWD) is a bleeding disorder caused by an abnormality of the von Willebrand factor protein.

Case presentation

Two brothers diagnosed with VWD came to our clinic, the older for caries treatment and the younger for extraction of primary teeth. To control intraoperative bleeding and postoperative hemostasis, the older brother received plasma-derived/factor VIII concentrate intravenously the day before dental treatment, while the younger brother received desmopressin preoperatively, as that was found to be effective.