用于治疗胰岛素抵抗和糖尿病的人参皂甙:治疗视角和机理见解

IF 6.8 2区 医学 Q1 CHEMISTRY, MEDICINAL Journal of Ginseng Research Pub Date : 2024-03-22 DOI:10.1016/j.jgr.2024.03.002
Tae Hyun Kim
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引用次数: 0

摘要

糖尿病(DM)是一种全身性能量代谢紊乱,其特点是血糖持续升高,同时多个外周组织的胰岛素作用受损(即胰岛素抵抗)。尽管已经开展了大量研究来确定治疗糖尿病的靶点,但糖尿病的全球发病率和相关死亡率仍在上升,这可能是由于目前可用药物的长期依从性、有限的疗效和不良副作用所带来的挑战,这意味着开发有效、安全的糖尿病药物疗法迫在眉睫。最近,植物化学物质因其临床相关性、疗效和安全性而作为治疗 DM 的新型药物疗法引起了人们的关注。人参皂甙是主要存在于人参中的药理活性成分,在亚洲国家长期以来一直被用作传统药物的辅助剂,据报道对包括高血糖和糖尿病在内的各种代谢性疾病具有良好的疗效。本综述总结了目前人参皂苷的药理作用及其治疗胰岛素抵抗和糖尿病的机理,为开发治疗糖尿病及相关代谢并发症的新策略提供了全面的视角。
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Ginsenosides for the treatment of insulin resistance and diabetes: Therapeutic perspectives and mechanistic insights

Diabetes mellitus (DM) is a systemic disorder of energy metabolism characterized by a sustained elevation of blood glucose in conjunction with impaired insulin action in multiple peripheral tissues (i.e., insulin resistance). Although extensive research has been conducted to identify therapeutic targets for the treatment of DM, its global prevalence and associated mortailty rates are still increasing, possibly because of challenges related to long-term adherence, limited efficacy, and undesirable side effects of currently available medications, implying an urgent need to develop effective and safe pharmacotherapies for DM. Phytochemicals have recently drawn attention as novel pharmacotherapies for DM based on their clinical relevance, therapeutic efficacy, and safety. Ginsenosides, pharmacologically active ingredients primarily found in ginseng, have long been used as adjuvants to traditional medications in Asian countries and have been reported to exert promising therapeutic efficacy in various metabolic diseases, including hyperglycemia and diabetes. This review summarizes the current pharmacological effects of ginsenosides and their mechanistic insights for the treatment of insulin resistance and DM, providing comprehensive perspectives for the development of novel strategies to treat DM and related metabolic complications.

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来源期刊
Journal of Ginseng Research
Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE
CiteScore
11.40
自引率
9.50%
发文量
111
审稿时长
6-12 weeks
期刊介绍: Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.
期刊最新文献
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