重症监护室的内分泌急症:自身免疫性多腺体综合征伴肾上腺危象和晚期心脏传导阻滞:病例报告

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引用次数: 0

摘要

我们介绍了一例罕见的急诊病例,该病例具有多种风险因素和多种病因,如不及时诊断和治疗,死亡率很高。了解并链接该病例的描述有助于科学界为应对类似的罕见情况做好准备。这是一名 48 岁的患者,有多腺自身免疫综合征病史,正在接受皮质类固醇治疗,因气喘、腺痛、乏力和多饮而就诊。临床表现为低血压、低血糖、水电解质紊乱、酸碱失衡、促甲状腺激素(TSH)升高、游离甲状腺素(T4L)降低和副甲状腺激素(PTH)偏低。她被诊断为肾上腺危象,并被送入重症监护室。在重症监护室(ICU)住院期间,她出现了晚期心脏传导阻滞,需要植入心脏起搏器并进行适当的治疗。肾上腺危象是一种罕见疾病,即使已知有肾上腺功能不全的病史,诊断时也需要高度怀疑。有必要彻底调查病史、背景、临床表现、皮质类固醇治疗的依从性,进行全面的体格检查,并要求进行相关的辅助检查以进行综合评估。认识到心脏传导阻滞可能是类固醇治疗的难治性疾病,需要电支持对患者的生存至关重要。
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Urgencias endocrinas en la unidad de cuidados intensivos: síndrome poliglandular autoinmune con crisis adrenal y bloqueo cardíaco avanzado: reporte de un caso

We present a case of a rare medical emergency with multiple risk factors and several causes, with high mortality when not diagnosed and treated in a timely manner. Knowing and linking to the description of this case can help the scientific community prepare for rare situations like this. This is a 48-year-old patient with a history of polyglandular autoimmune syndrome under treatment with corticosteroids, who consulted for asthenia, adynamia, weakness and polydipsia. Clinically, hypotension, hypoglycemia, hydroelectrolyte disturbances, acid-base imbalance, elevated thyroid stimulating hormone (TSH) with decreased free thyroxine (T4L) and low paratohormone (PTH) were identified. An adrenal crisis was diagosticated and was admitted to the ICU. During her stay in the intensive care unit (ICU), she presented with an advanced cardiac block that required a pacemaker implant with appropriate evolution. Adrenal crisis is a rare condition, diagnosis requires a high rate of suspicion even when the history of adrenal insufficiency is known. It is necessary to investigate thoroughly the history, background, clinical manifestations, adherence to corticosteroid therapy, perform a complete physical examination and request relevant paraclinical studies for a comprehensive evaluation. Recognize that cardiac block may be refractory to steroid therapy and require electrical support may be essential for patient survival.

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