Juliana B Teixeira, Maria A T Bortolini, Rebecca S P Silva, Nilce C Batista, Carolina L Costa E Silva, Kristina Allen-Brady, Rodrigo A Castro
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A logistic regression model was used with <i>p</i> < 0.05 for significance.</p><p><strong>Results: </strong>A total of 565 participants were evaluated (325 POP and 240 control). The homozygous C allele of rs2018736 (CC) was protective against POP (odds ratio [OR] 0.49, 95% confidence interval [CI] 0.26-0.91). 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引用次数: 0
摘要
目的：纤维素-5是一种结缔组织成分，可能在盆腔器官脱垂（POP）发病机制中发挥作用。本研究旨在验证巴西绝经后妇女纤维蛋白-5 基因 rs2018736 多态性与 POP 的相关性，并确定 POP 的风险因素：这项观察性、横断面、病例对照研究通过检查和采集外周血样本，对患有晚期 POP（III 期和 IV 期）的绝经后妇女和对照组妇女（0 期和 I 期）进行了评估。DNA 序列通过实时逆转录酶聚合酶链反应进行分析。采用逻辑回归模型，P 结果：共评估了 565 名参与者（325 名 POP 和 240 名对照组）。rs2018736的等位基因C（CC）对POP具有保护作用（几率比[OR]0.49，95%置信区间[CI]0.26-0.91）。0011）、POP 家族史（OR 2.35，95% CI 1.24-4.44）、高血压（OR 1.74，95% CI 1.01-3.00）和糖尿病（OR 2.19，95% CI 1.07-4.48）]是 POP 的独立预测因素；剖宫产（OR 0.02，95% CI 0.005-0.09）具有保护作用：结论：纤维蛋白-5 基因的 rs2018736-CC 基因型对 POP 有保护作用。
The rs2018736 fibulin-5 polymorphism as a determinant for pelvic organ prolapse: a case-control study.
Objective: Fibulin-5 is a connective tissue component and may play a role in pelvic organ prolapse (POP) pathogenesis. This study aimed to verify the association of the rs2018736 polymorphism of the fibulin-5 gene with POP in postmenopausal Brazilian women, and to determine the risk factors for POP.
Method: This observational, cross-sectional, case-control study assessed postmenopausal women with advanced POP (stages III and IV) and control women (stages 0 and I) by examination and peripheral blood sample collection. DNA sequences were analyzed by real-time reverse-transcriptase polymerase chain reaction. A logistic regression model was used with p < 0.05 for significance.
Results: A total of 565 participants were evaluated (325 POP and 240 control). The homozygous C allele of rs2018736 (CC) was protective against POP (odds ratio [OR] 0.49, 95% confidence interval [CI] 0.26-0.91). Age (OR 1.09, 95% CI 1.05-1.13), number of pregnancies (OR 1.14, 95% CI 1.01-1.28), vaginal delivery (OR 5.32, 95% CI 2.58-11.01), forceps delivery (OR 3.34, 95% CI 1.72-6.47), weight of newborn (OR 1.0007, 95% CI 1.0002-1.0011), family history of POP (OR 2.35, 95% CI 1.24-4.44), hypertension (OR 1.74, 95% CI 1.01-3.00) and diabetes (OR 2.19, 95% CI 1.07-4.48)] were independent predictors for POP; cesarean (OR 0.02, 95% CI 0.005-0.09) was protective.
Conclusion: The rs2018736-CC genotype of the fibulin-5 gene has a protective role against POP.
期刊介绍：
Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women.
Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments.
The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.
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