我们的大脑如何处理积极和消极的热感线索?

IF 5.3 2区 医学 Q1 PHYSIOLOGY Physiology Pub Date : 2024-07-01 Epub Date: 2024-03-27 DOI:10.1152/physiol.00034.2023
Jose G Grajales-Reyes, Bandy Chen, David Meseguer, Marc Schneeberger
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引用次数: 0

摘要

无论是夏季热浪带来的令人窒息的剧烈感觉,还是寒冷天气中一杯热饮带来的积极强化作用,我们肯定都同意,热环境是我们日常感觉节奏的基础。大量研究都集中在破译负责传递产热对哺乳动物行为影响的中枢回路上。在此,我们将对近期负责定义哺乳动物产热波动所产生的行为相关性的文献进行修订。我们从热感觉的生理意义过渡到负责与之相关的自律神经或行为反应的电路。随后,我们深入探讨了体温调节过程所编码的积极和消极情绪。重要的是,我们强调了奖赏、疼痛和体温调节相互交叉的关键节点,揭示了这些神经回路内部复杂的相互作用。最后,我们简要概述了该领域有待解决的基本问题。完全破解哺乳动物的体温调节回路将产生深远的医学影响。例如,它可能导致确定克服热痛的新目标,或允许在长时间手术中保持我们的核心温度。
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Burning Question: How Does Our Brain Process Positive and Negative Cues Associated with Thermosensation?

Whether it is the dramatic suffocating sensation from a heat wave in the summer or the positive reinforcement arising from a hot drink on a cold day; we can certainly agree that our thermal environment underlies our daily rhythms of sensation. Extensive research has focused on deciphering the central circuits responsible for conveying the impact of thermogenesis on mammalian behavior. Here, we revise the recent literature responsible for defining the behavioral correlates that arise from thermogenic fluctuations in mammals. We transition from the physiological significance of thermosensation to the circuitry responsible for the autonomic or behavioral responses associated with it. Subsequently, we delve into the positive and negative valence encoded by thermoregulatory processes. Importantly, we emphasize the crucial junctures where reward, pain, and thermoregulation intersect, unveiling a complex interplay within these neural circuits. Finally, we briefly outline fundamental questions that are pending to be addressed in the field. Fully deciphering the thermoregulatory circuitry in mammals will have far-reaching medical implications. For instance, it may lead to the identification of novel targets to overcome thermal pain or allow the maintenance of our core temperature in prolonged surgeries.

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来源期刊
Physiology
Physiology 医学-生理学
CiteScore
14.50
自引率
0.00%
发文量
37
期刊介绍: Physiology journal features meticulously crafted review articles penned by esteemed leaders in their respective fields. These articles undergo rigorous peer review and showcase the forefront of cutting-edge advances across various domains of physiology. Our Editorial Board, comprised of distinguished leaders in the broad spectrum of physiology, convenes annually to deliberate and recommend pioneering topics for review articles, as well as select the most suitable scientists to author these articles. Join us in exploring the forefront of physiological research and innovation.
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