Effect of Various Sweeteners on Glycogen Content of Blood Leukocytes and Differential Leukocyte Count in C57BL/6 Mice

Abstract

The effect of stevia leaf extract, saccharinate, and cyclamate in various dosages on the glycogen content of blood leukocytes in C57BL/6 mice as a necessary substrate for the realization of phagocytosis was studied. An increase in glycogen content was found in all experimental groups treated with sweeteners at a dosage of 10 mg/g of body weight. The effect of sweeteners on the differential leukocyte counts was found only in mice receiving the stevia leaf extract at a dosage of 10 mg/g of body weight manifested as an increase neutrophil-to-lymphocyte ratio (NLR). The data obtained expand our understanding of the metabolism of sugar substitutes in an organism and their influence on physiological systems, in particular, the hematopoietic and immune systems.