通过统一健康方法推进流感预防工作:综合分析

IF 5.4 Q2 ENGINEERING, ENVIRONMENTAL Journal of hazardous materials advances Pub Date : 2024-03-28 DOI:10.1016/j.hazadv.2024.100419
Riya Mukherjee , Gunjan K , Himanshu K , Jasmina Vidic , Ramendra Pati Pandey , Chung-Ming Chang
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引用次数: 0

摘要

背景流感是一个全球性的健康问题,利用纳米粒子疫苗或药物预防和治疗流感是一个很有前景的解决方案。纳米颗粒具有药物分布精确、药效更强、不良反应最小等特点,作为抗击流感的可行候选药物备受关注。本荟萃分析评估了纳米粒子,尤其是含有姜黄素等天然化合物的纳米粒子在流感预防和治疗中的有效性、安全性和潜在应用。方法 通过系统的文献检索,收集并检查了有关基于纳米粒子的流感预防和治疗策略的研究,重点是姜黄素等天然化合物。研究结果表明,纳米粒子能显著提高流感预防效果。在动物模型中,纳米颗粒干预措施显示出更强的抗病毒活性,从而大幅降低了病毒载量,提高了存活率。纳米颗粒的精确给药使药物在感染部位的浓度更高,从而最大限度地提高了治疗效果。值得注意的是,与传统的抗病毒药物相比,基于纳米粒子的疗法具有更高的安全性,细胞毒性最小,副作用更少。植物化学物质与纳米粒子的结合为流感治疗提供了一个前景广阔的途径,它提供了具有固有天然特性的持久疗法,增强了抗病毒活性。植物化学物质和纳米粒子的协同作用为抗病毒药物的开发开辟了新途径。 总之,纳米粒子在治疗流感方面既有效又安全,由于其靶向给药和增强的抗病毒活性,可作为有效的治疗药物。植物化学物质的加入进一步增强了其潜力。未来的研究工作应侧重于改进纳米粒子配方、阐明其作用机制以及探索创新的组合策略。纳米粒子在流感治疗中的革命性影响有望推动抗病毒药物的发展,并最终改善患者的治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Advancing influenza prevention through a one health approach: A comprehensive analysis

Background

Influenza represents a global One Health concern, and the utilization of nanoparticle-based vaccines or drugs emerges as a promising solution for its prevention and treatment. Nanoparticles, with their precision in drug distribution, heightened efficacy, and minimized adverse effects, have garnered attention as viable candidates in the fight against influenza. This meta-analysis assesses the effectiveness, safety, and potential applications of nanoparticles, particularly those incorporating natural compounds like curcumin, in influenza prevention and treatment.

Methods

A systematic literature search was conducted to gather and examine studies focusing on nanoparticle-based strategies for influenza prevention and treatment, with a specific emphasis on natural compounds such as curcumin. The results obtained were meticulously evaluated.

Findings

The results indicate that nanoparticles significantly enhance the effectiveness of influenza prevention. In animal models, nanoparticle interventions exhibit heightened antiviral activity, leading to a substantial reduction in viral load and improved survival rates. The precision of drug administration enabled by nanoparticles facilitates higher drug concentrations at the infection site, maximizing therapeutic benefits. Notably, nanoparticle-based therapies exhibit superior safety profiles compared to traditional antiviral medications, with minimal cytotoxicity and fewer side effects. The combination of phytochemicals with nanoparticles offers a promising avenue for influenza treatment, providing durable therapeutic alternatives with inherent natural qualities that enhance antiviral activity. The synergistic effect of phytochemicals and nanoparticles opens new avenues for the development of antiviral agents.

Conclusion

In conclusion, nanoparticles demonstrate both efficacy and safety in the treatment of influenza, acting as potent therapeutic agents due to their targeted drug delivery and enhanced antiviral activities. The inclusion of phytochemicals further amplifies their potential. Future research endeavours should focus on refining nanoparticle formulations, elucidating their mechanisms of action, and exploring innovative combinatorial strategies. The revolutionary impact of nanoparticles in influenza treatment holds the promise of advancing antiviral medicines and ultimately improving patient outcomes.

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来源期刊
Journal of hazardous materials advances
Journal of hazardous materials advances Environmental Engineering
CiteScore
4.80
自引率
0.00%
发文量
0
审稿时长
50 days
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