在健康男性面临各种血糖挑战时,血清骨甘氨酸保持稳定。

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2024-09-01 Epub Date: 2024-03-28 DOI:10.1007/s12020-024-03789-1
Jakob Starup-Linde, Sidse Westberg-Rasmussen, Rikke Viggers, Zheer Kejlberg Al-Mashhadi, Aase Handberg, Peter Vestergaard, Søren Gregersen
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引用次数: 0

摘要

目的:骨肽被认为具有代谢活性,可增强胰岛素的作用。我们假设,骨肽酶水平在高血糖时会升高,这是增强胰岛素作用的一种生理反应:方法:8 名健康男性参加了一项交叉研究,该研究包括禁食 8 小时后的三个研究日。首先,我们进行了口服葡萄糖耐量试验(OGTT);其次,进行了等血糖静脉葡萄糖输注(IIGI);第三,进行了禁食三小时的对照期。我们分析了研究期间血液样本中的循环骨化甘肽水平。我们进行了重复测量方差分析,以比较 OGTT、IIGI 和空腹对照组的 s-osteoglycin 水平:结果:不同研究日的骨钙素基线水平没有差异(P > 0.05)。我们观察到,s-骨酵素绝对水平在不同时间(p = 0.14)和不同研究日(p = 0.99)均无明显变化。同样,我们也没有观察到 s-osteoglycin 的百分比水平随时间(p = 0.11)或随研究日(p = 0.89)发生明显变化:我们发现,健康男性在OGTT、IIGI和空腹时,s-骨化甘肽水平在三小时内保持稳定。根据本研究,循环中的 s-osteoglycin 水平可以不受空腹或非空腹条件的影响。此外,循环中生理水平的葡萄糖和胰岛素不会影响 s-osteoglycin 的水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Serum osteoglycin is stable during various glycemic challenges in healthy men.

Purpose: Osteoglycin is hypothesized to be metabolically active and may enhance insulin action. We hypothesized that osteoglycin levels increase during hyperglycemia as a physiological response to enhance the effects of insulin.

Methods: Eight healthy males were included in a cross-over study consisting of three study days following an 8 h fast. First, we performed an oral glucose tolerance test (OGTT); second, an isoglycemic intravenous glucose infusion (IIGI); and third, a control period consisting of a three hour fast. We analyzed blood samples for circulating osteoglycin levels during the study days. Repeated measures ANOVA was performed to compare levels of s-osteoglycin between OGTT, IIGI, and the fasting control.

Results: There were no differences in baseline osteoglycin levels among study days (p > 0.05). We observed no significant changes neither in absolute s-osteoglycin levels by time (p = 0.14) nor over time by study day (p = 0.99). Likewise, we observed no significant changes in percentage s-osteoglycin levels neither by time (p = 0.11) nor over time by study day (p = 0.89).

Conclusion: We found that s-osteoglycin levels were stable for three hours during OGTT, IIGI, and fasting in healthy males. Based on the present study, circulating s-osteoglycin levels may be measured independently of fasting or non-fasting conditions. Furthermore, circulating physiological levels of glucose and insulin did not affect s-osteoglycin levels.

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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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