{"title":"纳米粒子能否为治疗自闭症谱系障碍带来希望？","authors":"","doi":"10.1007/s40489-024-00452-3","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <p>Autism spectrum disorder (ASD) presents lifelong neurodevelopmental challenges and is diagnosed in early childhood. ASD is complex, has multiple causes, and is characterized by communication difficulties, impaired social interaction, and repetitive behaviors. Unfortunately, there are no specific biomarkers for diagnosis or effective treatments yet. However, nanomedicine offers promise for treating central nervous system (CNS) disorders conditions, including ASD. Nanomaterials can cross the blood–brain barrier, target specific cells, disseminate in brain tissue, and serve as carriers for therapeutics. This review emphasizes the importance and potential of nanomedicine, current pharmacological treatments for ASD, challenges in drug development, and recent medical approaches based on nanotechnology to overcome the blood brain barrier and deliver CNS therapeutics. Neurobiological research for future nanomedicine applications will also be highlighted.</p>","PeriodicalId":46647,"journal":{"name":"Review Journal of Autism and Developmental Disorders","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Would Nanoparticles Give Hope for the Treatment of Autism Spectrum Disorder?\",\"authors\":\"\",\"doi\":\"10.1007/s40489-024-00452-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h3>Abstract</h3> <p>Autism spectrum disorder (ASD) presents lifelong neurodevelopmental challenges and is diagnosed in early childhood. ASD is complex, has multiple causes, and is characterized by communication difficulties, impaired social interaction, and repetitive behaviors. Unfortunately, there are no specific biomarkers for diagnosis or effective treatments yet. However, nanomedicine offers promise for treating central nervous system (CNS) disorders conditions, including ASD. Nanomaterials can cross the blood–brain barrier, target specific cells, disseminate in brain tissue, and serve as carriers for therapeutics. This review emphasizes the importance and potential of nanomedicine, current pharmacological treatments for ASD, challenges in drug development, and recent medical approaches based on nanotechnology to overcome the blood brain barrier and deliver CNS therapeutics. Neurobiological research for future nanomedicine applications will also be highlighted.</p>\",\"PeriodicalId\":46647,\"journal\":{\"name\":\"Review Journal of Autism and Developmental Disorders\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-03-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Review Journal of Autism and Developmental Disorders\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1007/s40489-024-00452-3\",\"RegionNum\":3,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PSYCHOLOGY, DEVELOPMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Review Journal of Autism and Developmental Disorders","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1007/s40489-024-00452-3","RegionNum":3,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PSYCHOLOGY, DEVELOPMENTAL","Score":null,"Total":0}
Would Nanoparticles Give Hope for the Treatment of Autism Spectrum Disorder?
Abstract
Autism spectrum disorder (ASD) presents lifelong neurodevelopmental challenges and is diagnosed in early childhood. ASD is complex, has multiple causes, and is characterized by communication difficulties, impaired social interaction, and repetitive behaviors. Unfortunately, there are no specific biomarkers for diagnosis or effective treatments yet. However, nanomedicine offers promise for treating central nervous system (CNS) disorders conditions, including ASD. Nanomaterials can cross the blood–brain barrier, target specific cells, disseminate in brain tissue, and serve as carriers for therapeutics. This review emphasizes the importance and potential of nanomedicine, current pharmacological treatments for ASD, challenges in drug development, and recent medical approaches based on nanotechnology to overcome the blood brain barrier and deliver CNS therapeutics. Neurobiological research for future nanomedicine applications will also be highlighted.
期刊介绍：
The Review Journal of Autism and Developmental Disorders publishes original articles that provide critical reviews of topics across the broad interdisciplinary research fields of autism spectrum disorders. Topics range from basic to applied and include but are not limited to genetics, neuroscience, diagnosis, applied behavior analysis, psychopharmacology, incidence, prevalence, etiology, differential diagnosis, treatment, measurement of treatment effects, education, perception and cognition. Topics across the life span are appropriate. In addition, given the high rates of comorbid conditions, the interface of sleep disorders, feeding problems, motor difficulties, ADHD, anxiety, depression and other disorders with autism spectrum disorders are appropriate. The Journal aims for an international audience as reflected in the editorial board.
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