纳米粒子能否为治疗自闭症谱系障碍带来希望?

IF 2.9 3区 心理学 Q2 PSYCHOLOGY, DEVELOPMENTAL Review Journal of Autism and Developmental Disorders Pub Date : 2024-03-28 DOI:10.1007/s40489-024-00452-3
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引用次数: 0

摘要

摘要 自闭症谱系障碍(ASD)是一种终身性神经发育障碍,在儿童早期即可诊断出来。自闭症的病因复杂多样,主要表现为沟通障碍、社会交往障碍和重复行为。遗憾的是,目前还没有用于诊断或有效治疗的特定生物标志物。不过,纳米医学为治疗中枢神经系统(CNS)疾病(包括 ASD)带来了希望。纳米材料可以穿过血脑屏障,靶向特定细胞,在脑组织中扩散,并作为治疗药物的载体。本综述强调了纳米医学的重要性和潜力、目前针对 ASD 的药物治疗方法、药物开发面临的挑战以及最近基于纳米技术克服血脑屏障和输送中枢神经系统治疗药物的医学方法。此外,还将重点介绍未来纳米医学应用的神经生物学研究。
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Would Nanoparticles Give Hope for the Treatment of Autism Spectrum Disorder?

Abstract

Autism spectrum disorder (ASD) presents lifelong neurodevelopmental challenges and is diagnosed in early childhood. ASD is complex, has multiple causes, and is characterized by communication difficulties, impaired social interaction, and repetitive behaviors. Unfortunately, there are no specific biomarkers for diagnosis or effective treatments yet. However, nanomedicine offers promise for treating central nervous system (CNS) disorders conditions, including ASD. Nanomaterials can cross the blood–brain barrier, target specific cells, disseminate in brain tissue, and serve as carriers for therapeutics. This review emphasizes the importance and potential of nanomedicine, current pharmacological treatments for ASD, challenges in drug development, and recent medical approaches based on nanotechnology to overcome the blood brain barrier and deliver CNS therapeutics. Neurobiological research for future nanomedicine applications will also be highlighted.

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来源期刊
CiteScore
8.40
自引率
0.00%
发文量
51
期刊介绍: The Review Journal of Autism and Developmental Disorders publishes original articles that provide critical reviews of topics across the broad interdisciplinary research fields of autism spectrum disorders. Topics range from basic to applied and include but are not limited to genetics, neuroscience, diagnosis, applied behavior analysis, psychopharmacology, incidence, prevalence, etiology, differential diagnosis, treatment, measurement of treatment effects, education, perception and cognition. Topics across the life span are appropriate. In addition, given the high rates of comorbid conditions, the interface of sleep disorders, feeding problems, motor difficulties, ADHD, anxiety, depression and other disorders with autism spectrum disorders are appropriate. The Journal aims for an international audience as reflected in the editorial board.
期刊最新文献
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