Aitor Blanco-Míguez, Sara Carloni, Cindy Cardenas, Carola Conca Dioguardi, Luca Lambroia, Giovanni Capretti, Gennaro Nappo, Alessandro Fugazza, Antonio Capogreco, Federica Armanini, Francesco Asnicar, Leonard Dubois, Davide Golzato, Paolo Manghi, Federica Pinto, Cristina Scuderi, Erminia Casari, Marco Montorsi, Andrea Anderloni, Maria Rescigno, Alessandro Repici, Alessandro Zerbi, Clelia Peano, Sabrina Tamburini, Roberto Rusconi, Nicola Segata
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Microbial composition associated with biliary stents in patients undergoing pancreatic resection for cancer.
Malignant bile duct obstruction is typically treated by biliary stenting, which however increases the risk of bacterial infections. Here, we analyzed the microbial content of the biliary stents from 56 patients finding widespread microbial colonization. Seventeen of 36 prevalent stent species are common oral microbiome members, associate with disease conditions when present in the gut, and include dozens of biofilm- and antimicrobial resistance-related genes. This work provides an overview of the microbial communities populating the stents.
期刊介绍：
npj Biofilms and Microbiomes is a comprehensive platform that promotes research on biofilms and microbiomes across various scientific disciplines. The journal facilitates cross-disciplinary discussions to enhance our understanding of the biology, ecology, and communal functions of biofilms, populations, and communities. It also focuses on applications in the medical, environmental, and engineering domains. The scope of the journal encompasses all aspects of the field, ranging from cell-cell communication and single cell interactions to the microbiomes of humans, animals, plants, and natural and built environments. The journal also welcomes research on the virome, phageome, mycome, and fungome. It publishes both applied science and theoretical work. As an open access and interdisciplinary journal, its primary goal is to publish significant scientific advancements in microbial biofilms and microbiomes. The journal enables discussions that span multiple disciplines and contributes to our understanding of the social behavior of microbial biofilm populations and communities, and their impact on life, human health, and the environment.
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