Yasemin Budama-Kilinc, Ozan Baris Kurtur, Bahar Gok, Nisanur Cakmakci, Serda Kecel-Gunduz, Necdet Mehmet Unel, Taylan Kurtulus Ozturk
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引用次数: 0
摘要
从古至今,呼吸道病毒已造成多次大流行,并因其传播速度快而成为全球公共卫生的首要问题之一。最近发生的 COVID-19 大流行使人们认识到快速诊断检测对预防流行病的重要性以及开发新疫苗的困难。另一方面,在治疗过程中出现的对现有抗病毒药物的抗药性也给社会和全球卫生系统带来了重大问题。因此,需要新的方法来诊断、预防和治疗现有或新型呼吸道病毒。从禽蛋蛋黄中提取的免疫球蛋白 Y 抗体(IgYs)具有产量高、生产成本低、选择性强等显著优势,可用于开发创新型战略产品。特别是在诊断呼吸道病毒方面,集成了这些抗体的基于抗体的生物传感器有可能作为一种实用的诊断工具,在快速准确诊断方面提供优越性。这篇综述文章旨在介绍 IgY 抗体在呼吸道病毒诊断、预防和治疗中的应用,并为未来的创新应用提供展望。
Use of Immunoglobulin Y Antibodies: Biosensor-based Diagnostic Systems and Prophylactic and Therapeutic Drug Delivery Systems for Viral Respiratory Diseases.
Respiratory viruses have caused many pandemics from past to present and are among the top global public health problems due to their rate of spread. The recently experienced COVID-19 pandemic has led to an understanding of the importance of rapid diagnostic tests to prevent epidemics and the difficulties of developing new vaccines. On the other hand, the emergence of resistance to existing antiviral drugs during the treatment process poses a major problem for society and global health systems. Therefore, there is a need for new approaches for the diagnosis, prophylaxis, and treatment of existing or new types of respiratory viruses. Immunoglobulin Y antibodies (IgYs) obtained from the yolk of poultry eggs have significant advantages, such as high production volumes, low production costs, and high selectivity, which enable the development of innovative and strategic products. Especially in diagnosing respiratory viruses, antibody-based biosensors in which these antibodies are integrated have the potential to provide superiority in making rapid and accurate diagnosis as a practical diagnostic tool. This review article aims to provide information on using IgY antibodies in diagnostic, prophylactic, and therapeutic applications for respiratory viruses and to provide a perspective for future innovative applications.
期刊介绍:
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.