牙周炎与胃肠道疾病的关系:孟德尔随机双向研究

IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of periodontology Pub Date : 2024-04-02 DOI:10.1002/JPER.23-0560
Yuqiang Wang, Jiakang Zhu, Ying Tang, Cui Huang
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引用次数: 0

摘要

背景:以往的流行病学研究已对牙周炎(PD)与胃肠道疾病(GIT)的双向联系进行了调查,但结论仍存在争议。本研究旨在全面探讨牙周炎与各种胃肠道疾病之间的双向因果效应:方法:基于全基因组关联研究(GWAS)的摘要级数据,开展了一项双样本双向孟德尔随机化(MR)研究。将全基因组关联研究中与腹泻或胃肠道疾病(慢性胃炎[CG]、胃溃疡[GU]、十二指肠溃疡[DU]、胃食管反流病[GERD]、肠易激综合征[IBS]和肠憩室疾病[DI])相关的单核苷酸多态性(SNPs)作为暴露。采用的主要方法是逆方差加权法(IVW),并进行了几种敏感性分析,以研究潜在的多重效应:关于腹泻症与消化道疾病之间因果关系的调查,IVW 方法显示腹泻症对 GU(几率比 [OR] 1.088;95% 置信区间 [CI],1.036-1.141;调整后 p = 0.004)和 DI(OR 0.938;95% CI,0.911-0.965;调整后 p = 0.000)有因果影响。然而,在PD对CG、DU、胃食管反流病和肠易激综合征的因果效应方面,没有观察到明显的遗传责任。此外,主要分析也未显示胃肠道疾病对腹泻的因果效应:这项磁共振研究表明,PD 可能与 GU 风险增加和 DI 风险降低有关,但临床意义可能有限。需要进一步的研究来支持这项 MR 研究的结论。
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Association of periodontitis with gastrointestinal tract disorders: A bidirectional Mendelian randomization study

Background

The bidirectional link of periodontitis (PD) and gastrointestinal tract (GIT) disorders has been investigated in previous epidemiological studies; however, the conclusions still remain controversial. The aim of this study was to comprehensively explore the bidirectional causal effect between PD and various GIT diseases.

Methods

Based on summary-level data of genome-wide association studies (GWASs), a two-sample bidirectional Mendelian randomization (MR) study was undertaken. Single-nucleotide polymorphisms (SNPs) associated with PD or GIT disorders (chronic gastritis [CG], gastric ulcer [GU], duodenal ulcer [DU], gastroesophageal reflux disease [GERD], irritable bowel syndrome [IBS], and diverticular disease of the intestine [DI]) in GWASs were applied as exposure. The primary method employed was the inverse-variance weighted (IVW) method, and several sensitivity analyses were performed to investigate potential pleiotropy.

Results

With regard to the investigation of the causality between PD and GIT disorders, the IVW method revealed that there is a causal impact of PD on GU (odds ratio [OR] 1.088; 95% confidence interval [CI], 1.036–1.141; adjusted p = 0.004) and DI (OR 0.938; 95% CI, 0.911–0.965; adjusted p = 0.000). However, no significant genetic liability was observed for the causal effect of PD on CG, DU, GERD, and IBS. Furthermore, the primary analysis did not demonstrate a causal effect of GIT disorders on PD.

Conclusion

This MR study suggests that PD may be associated with an increased risk of GU and a reduced risk of DI, with possibly limited clinical relevance. Further studies are needed to support the conclusions of this MR study.

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来源期刊
Journal of periodontology
Journal of periodontology 医学-牙科与口腔外科
CiteScore
9.10
自引率
7.00%
发文量
290
审稿时长
3-8 weeks
期刊介绍: The Journal of Periodontology publishes articles relevant to the science and practice of periodontics and related areas.
期刊最新文献
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