利用 DCNN 评估热成像图像预测乳腺肿瘤分期的可行性

Zakaryae Khomsi, Mohamed El Fezazi, Achraf Elouerghi, L. Bellarbi
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摘要

早期乳腺癌和晚期乳腺癌代表着不同的疾病过程。因此,确定肿瘤的分期是优化治疗效率的关键步骤。乳腺热成像技术在无创肿瘤检测方面取得了重大进展。然而,根据温度分布准确判断肿瘤分期是一项具有挑战性的任务,这主要是由于标有肿瘤分期的热图像非常稀少。本研究提出了一种基于深度卷积神经网络(DCNN)和热图像的转移学习方法,用于预测乳腺肿瘤的分期。利用 COMSOL Multiphysics 软件提供的有限元法 (FEM),将包括早期和晚期肿瘤在内的各种肿瘤分期情况嵌入三维乳房模型。这样就可以生成用于训练 DCNN 模型的热图像数据集。对超参数调整过程进行了详细研究,以选择最佳预测模型。因此,使用混淆矩阵计算了各种评估指标,包括准确性、灵敏度和特异性。结果表明,DCNN 模型能够从热成像图像中准确预测乳腺肿瘤分期,准确率为 98.2%,灵敏度为 98.8%,特异性为 97.7%。这项研究表明,热成像图像在增强深度学习算法无创预测乳腺肿瘤分期方面具有巨大潜力。
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EVALUATING THE FEASIBILITY OF THERMOGRAPHIC IMAGES FOR PREDICTING BREAST TUMOR STAGE USING DCNN
Early-stage and advanced breast cancer represent distinct disease processes. Thus, identifying the stage of tumor is a crucial procedure for optimizing treatment efficiency. Breast thermography has demonstrated significant advancements in non-invasive tumor detection. However, the accurate determination of tumor stage based on temperature distribution represents a challenging task, primarily due to the scarcity of thermal images labeled with the stage of tumor. This work proposes a transfer learning approach based on Deep Convolutional Neural Network (DCNN) with thermal images for predicting breast tumor stage. Various tumor stage scenarios including early and advanced tumors are embedded in a 3D breast model using the Finite Element Method (FEM) available on COMSOL Multiphysics software. This allows the generation of the thermal image dataset for training the DCNN model. A detailed investigation of the hyperparameters tuning process has been conducted to select the optimal predictive model. Thus, various evaluation metrics, including accuracy, sensitivity, and specificity, are computed using the confusion matrix. The results demonstrate the DCNN model's ability to accurately predict breast tumor stage from thermographic images, with an accuracy of 98.2%, a sensitivity of 98.8%, and a specificity of 97.7%. This study indicates the promising potential of thermographic images in enhancing deep learning algorithms for the non-invasive prediction of breast tumor stage.
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