利用斯坦杰试验评估胎儿耐缺氧能力,作为阿普加量表评估新生儿健康状况的辅助手段

Petr D. Shabanov, Alexander L. Urakov, N. Urakova
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引用次数: 0

摘要

已经证实,死胎中胎儿生物学死亡的原因和活产中新生儿脑病的原因是胎儿缺氧性脑细胞损伤。面对致命的宫内缺氧,及时进行剖宫产仍是保护胎儿生命和健康的最有效方法。然而,目前还没有公认的方法来评估胎儿对缺氧的适应储备,也没有方法来选择分娩方式,以便在必要时及时进行剖宫产。自 1952 年开始使用的阿普加评分(Apgar score)可以评估新生儿在出生后 1 分钟和 5 分钟的健康状况,但这种评估没有考虑到胎儿在分娩前的健康状况。近年来,研究证实,胎儿缺氧的结果不仅取决于缺氧的持续时间,还取决于胎儿对缺氧的适应储备量。研究发现,孕妇呼吸暂停时胎儿不动的持续时间是胎儿耐缺氧能力的指标。2011 年,俄罗斯开发出了一种基于 Stange 试验的胎儿宫内耐缺氧能力评估方法。研究发现,在母体呼吸暂停时,胎儿不动的最长时间通常超过30秒,而在胎儿出现胎盘功能不全征象时,胎儿不动的最长时间达不到30秒,在出现严重胎盘功能不全征象时,胎儿不动的最长时间达不到10秒。因此,建议将胎儿耐缺氧能力良好作为阴道分娩的指征,将胎儿耐缺氧能力差作为剖宫产的指征。本文介绍了一种评估胎儿耐缺氧能力的技术,该技术已被开发出来,可供每位孕妇独立使用。结果表明,孕妇只需准备一个秒表,并记录下胎儿在自主呼吸暂停时的最长不动时间即可。希望胎儿耐缺氧能力的测量能成为新生儿健康阿普加(Apgar)评分的有益补充。预计使用改良的斯坦杰试验可帮助医生预防死胎和新生儿脑病。
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Assessment of fetal resistance to hypoxia using the Stange test as an adjunct to Apgar scale assessment of neonatal health status
It has been established that the cause of biological death of fetuses in stillbirths and the cause of neonatal encephalopathies in live births is hypoxic brain cell damage in fetuses. Timely cesarean section remains the most effective way to preserve fetal life and health in the face of lethal intrauterine hypoxia. However, there is no universally recognized methodology for assessing fetal adaptation reserves to hypoxia and no methodology for selecting the type of delivery in order to perform a timely cesarean section if necessary. The Apgar score, which has been used since 1952, allows assessment of neonatal health at 1 and 5 minutes after birth, but this assessment is made without taking into account the health of the fetus before delivery. In recent years, it has been established that the outcome of fetal hypoxia is determined not only by its duration, but also by the amount of adaptive reserves available in the fetus to hypoxia. It was found that the duration of fetal immobility during apnea of a pregnant woman is an indicator of fetal resistance to hypoxia. In 2011, a method of assessing fetal resistance to intrauterine hypoxia based on the Stange test was developed in Russia. It has been found that the maximum duration of fetal immobility during maternal apnea is normally more than 30 seconds, while in the presence of fetal signs of fetoplacental insufficiency it does not reach 30 seconds, and in the presence of signs of severe fetoplacental insufficiency it does not reach 10 seconds. Therefore, it was proposed to consider good fetal resistance to hypoxia as an indication for vaginal delivery, and poor fetal resistance to hypoxia as an indication for cesarean section. A technique for assessing fetal resistance to hypoxia is described that has been developed for independent use by every pregnant woman. It is shown that it is sufficient for her to have a stopwatch and to be able to record the maximum period of fetal immobility during voluntary apnea. It is hoped that a measure of fetal resistance to hypoxia could be a meaningful complement to the Apgar score of neonatal health. It is envisioned that the use of a modified Stange test could help physicians prevent stillbirths and neonatal encephalopathies.
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