内窥镜治疗尿道狭窄疾病的辅助疗法:过去、现在和未来

Jas Singh
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摘要

尿道狭窄症是一种反复发作、使人衰弱的疾病,影响着各个年龄段的许多男性。治疗方法包括内窥镜或手术治疗。手术尿道重建仍然是金标准治疗方法,在尿道狭窄复发率和存活率方面都有较高的成功率。不过,尿道成形术不适用于有严重内科合并症的患者或希望放弃侵入性手术的患者。内窥镜治疗的目的是改善下尿路症状,缓解梗阻,同时借助辅助治疗手段最大限度地延长狭窄复发时间。本综述旨在讨论辅助治疗药物的作用机制和作用,并重点介绍一些鲜为人知的辅助治疗药物,这些药物已在该领域获得成功应用。
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Therapeutic adjuncts in the endoscopic management of urethral stricture disease: past, present, and future
Urethral stricture disease is a recurrent and debilitating condition affecting many men of all ages. Management may involve endoscopic or surgical treatment. Surgical urethral reconstruction remains the gold standard treatment and is associated with higher success rates in terms of stricture recurrence free-survival. However, urethroplasty is not available to patients with significant medical comorbidities, or those wishing to forego invasive surgery. Endoscopic treatment is aimed at improving lower urinary tract symptoms and relieving obstruction while maximizing time to stricture recurrence with the aid of therapeutic adjuncts. The aim of this review is to discuss the mechanism of action and role of therapeutic adjuncts and highlight some of the lesser-known adjuncts that have been utilized with success in this space.
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