Pub Date : 2024-04-12DOI: 10.3389/fruro.2024.1329274
Irene de la Parra, Juan Gómez Rivas, Beatriz Gutíerrez, María Jesús Marugán, Dmitry Enikeev, B. Somani, Jerónimo Barrera, J. Moreno-Sierra
Since overdiagnosis and overtreatment pose significant risks in managing prostate cancer (PCa), active surveillance (AS) is the most common treatment in low-risk patients. However, there is no general agreement yet on the inclusion criteria and the required follow-up. Multiparametric magnetic resonance imaging (mpMRI) of the prostate was born as a useful device in these patients both in diagnosis and follow-up, and it is widely used in daily clinical practice. We reflect on the most current evidence described in the literature on the topic, its results, and our experience.
{"title":"The evolving landscape: magnetic resonance imaging in active surveillance for prostate cancer management","authors":"Irene de la Parra, Juan Gómez Rivas, Beatriz Gutíerrez, María Jesús Marugán, Dmitry Enikeev, B. Somani, Jerónimo Barrera, J. Moreno-Sierra","doi":"10.3389/fruro.2024.1329274","DOIUrl":"https://doi.org/10.3389/fruro.2024.1329274","url":null,"abstract":"Since overdiagnosis and overtreatment pose significant risks in managing prostate cancer (PCa), active surveillance (AS) is the most common treatment in low-risk patients. However, there is no general agreement yet on the inclusion criteria and the required follow-up. Multiparametric magnetic resonance imaging (mpMRI) of the prostate was born as a useful device in these patients both in diagnosis and follow-up, and it is widely used in daily clinical practice. We reflect on the most current evidence described in the literature on the topic, its results, and our experience.","PeriodicalId":503842,"journal":{"name":"Frontiers in Urology","volume":"11 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140712347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-27DOI: 10.3389/fruro.2024.1342941
Jas Singh
Urethral stricture disease is a recurrent and debilitating condition affecting many men of all ages. Management may involve endoscopic or surgical treatment. Surgical urethral reconstruction remains the gold standard treatment and is associated with higher success rates in terms of stricture recurrence free-survival. However, urethroplasty is not available to patients with significant medical comorbidities, or those wishing to forego invasive surgery. Endoscopic treatment is aimed at improving lower urinary tract symptoms and relieving obstruction while maximizing time to stricture recurrence with the aid of therapeutic adjuncts. The aim of this review is to discuss the mechanism of action and role of therapeutic adjuncts and highlight some of the lesser-known adjuncts that have been utilized with success in this space.
{"title":"Therapeutic adjuncts in the endoscopic management of urethral stricture disease: past, present, and future","authors":"Jas Singh","doi":"10.3389/fruro.2024.1342941","DOIUrl":"https://doi.org/10.3389/fruro.2024.1342941","url":null,"abstract":"Urethral stricture disease is a recurrent and debilitating condition affecting many men of all ages. Management may involve endoscopic or surgical treatment. Surgical urethral reconstruction remains the gold standard treatment and is associated with higher success rates in terms of stricture recurrence free-survival. However, urethroplasty is not available to patients with significant medical comorbidities, or those wishing to forego invasive surgery. Endoscopic treatment is aimed at improving lower urinary tract symptoms and relieving obstruction while maximizing time to stricture recurrence with the aid of therapeutic adjuncts. The aim of this review is to discuss the mechanism of action and role of therapeutic adjuncts and highlight some of the lesser-known adjuncts that have been utilized with success in this space.","PeriodicalId":503842,"journal":{"name":"Frontiers in Urology","volume":"24 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140375287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-28DOI: 10.3389/fruro.2023.1281081
Bağdagül Aksu, A. C. Afonso, I. Akil, H. Alpay, Bahriye Atmış, Ozlem Aydog, S. Bakkaloğlu, A. Bayazıt, M. Bayram, I. Bilge, I. Bulut, Ayşe Pınar Göksu Çetinkaya, Elif Comak, B. Demir, N. Dinçel, O. Donmez, Mehmet Akif Durmuş, Hasan Dursun, R. Dusunsel, A. Duzova, P. Ertan, A. Gedikbaşı, Nilufer Goknar, S. Guven, D. Hacıhamdioğlu, A. Jankauskienė, M. Kalyoncu, S. Kavukçu, Bahriye Uzun Kenan, Nuran Kuçuk, Bahar Kural, M. Litwin, Giovanni Montini, W. Morello, L. Obrycki, Beyhan Omer, Ebru Misirli Ozdemir, N. Ozkayın, D. Paripović, C. Pehlivanoğlu, S. Saygılı, F. Schaefer, S. Schaefer, F. Sonmez, Y. Tabel, Nesrin Taş, M. Taşdemir, Ana Teixeira, D. Tekcan, R. Topaloğlu, S. Tulpar, Ozde Nisa Turkkan, Berfin Uysal, M. Uysalol, R. Vitkevič, S. Yavuz, Sibel Yel, Tarık Yıldırım, Z. Yildirim, N. Yıldız, Selcuk Yuksel, E. Yurtseven, A. Yılmaz
Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes.Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA).uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05).Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.
{"title":"The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study","authors":"Bağdagül Aksu, A. C. Afonso, I. Akil, H. Alpay, Bahriye Atmış, Ozlem Aydog, S. Bakkaloğlu, A. Bayazıt, M. Bayram, I. Bilge, I. Bulut, Ayşe Pınar Göksu Çetinkaya, Elif Comak, B. Demir, N. Dinçel, O. Donmez, Mehmet Akif Durmuş, Hasan Dursun, R. Dusunsel, A. Duzova, P. Ertan, A. Gedikbaşı, Nilufer Goknar, S. Guven, D. Hacıhamdioğlu, A. Jankauskienė, M. Kalyoncu, S. Kavukçu, Bahriye Uzun Kenan, Nuran Kuçuk, Bahar Kural, M. Litwin, Giovanni Montini, W. Morello, L. Obrycki, Beyhan Omer, Ebru Misirli Ozdemir, N. Ozkayın, D. Paripović, C. Pehlivanoğlu, S. Saygılı, F. Schaefer, S. Schaefer, F. Sonmez, Y. Tabel, Nesrin Taş, M. Taşdemir, Ana Teixeira, D. Tekcan, R. Topaloğlu, S. Tulpar, Ozde Nisa Turkkan, Berfin Uysal, M. Uysalol, R. Vitkevič, S. Yavuz, Sibel Yel, Tarık Yıldırım, Z. Yildirim, N. Yıldız, Selcuk Yuksel, E. Yurtseven, A. Yılmaz","doi":"10.3389/fruro.2023.1281081","DOIUrl":"https://doi.org/10.3389/fruro.2023.1281081","url":null,"abstract":"Congenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes.Among patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA).uHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05).Urine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.","PeriodicalId":503842,"journal":{"name":"Frontiers in Urology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140418545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-26DOI: 10.3389/fruro.2023.1336179
Thomas Vincent T. Vergara, J. M. Magsanoc, Marvin Jonne Mendoza, Gerardo Tomas Cornelio, Rudolfo De Guzman, N. Magsanoc, Dennis Serrano
Prostate cancer (PCa) is a health concern affecting millions of men globally, with a concerning rise in incidence in the Philippines, a country that faces a complex set of barriers to equitable access to quality PCa care. In this article, we describe the unique geographic, economic, socio-cultural, and political factors that influence access to screening, diagnosis, treatment, and supportive services in the country, and explore avenues for development. The country lacks a nationwide PCa registry to inform resource allocation and guide PCa cancer care programs and policy. Misconceptions, cultural barriers and negative attitudes about PCa among Filipino men adversely influence health-seeking behavior. Inadequate insurance coverage, and high out-of-pocket costs obstruct access to essential care. Geographic and political factors contribute to the uneven distribution of healthcare resources needed for comprehensive PCa care, including access to medical specialists, essential medicines, and surgical and radiotherapeutic equipment. Overcoming these challenges requires a collaborative effort encompassing robust data collection, awareness campaigns to reshape societal norms, policy and economic reforms, infrastructure improvements, and enhanced collaboration among healthcare professionals to provide evidence-based care. Addressing these issues holistically can pave the way to better outcomes and improved quality of life for Filipino men with this life-altering disease.
{"title":"Overcoming barriers to prostate cancer care in the Philippines","authors":"Thomas Vincent T. Vergara, J. M. Magsanoc, Marvin Jonne Mendoza, Gerardo Tomas Cornelio, Rudolfo De Guzman, N. Magsanoc, Dennis Serrano","doi":"10.3389/fruro.2023.1336179","DOIUrl":"https://doi.org/10.3389/fruro.2023.1336179","url":null,"abstract":"Prostate cancer (PCa) is a health concern affecting millions of men globally, with a concerning rise in incidence in the Philippines, a country that faces a complex set of barriers to equitable access to quality PCa care. In this article, we describe the unique geographic, economic, socio-cultural, and political factors that influence access to screening, diagnosis, treatment, and supportive services in the country, and explore avenues for development. The country lacks a nationwide PCa registry to inform resource allocation and guide PCa cancer care programs and policy. Misconceptions, cultural barriers and negative attitudes about PCa among Filipino men adversely influence health-seeking behavior. Inadequate insurance coverage, and high out-of-pocket costs obstruct access to essential care. Geographic and political factors contribute to the uneven distribution of healthcare resources needed for comprehensive PCa care, including access to medical specialists, essential medicines, and surgical and radiotherapeutic equipment. Overcoming these challenges requires a collaborative effort encompassing robust data collection, awareness campaigns to reshape societal norms, policy and economic reforms, infrastructure improvements, and enhanced collaboration among healthcare professionals to provide evidence-based care. Addressing these issues holistically can pave the way to better outcomes and improved quality of life for Filipino men with this life-altering disease.","PeriodicalId":503842,"journal":{"name":"Frontiers in Urology","volume":"42 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140431523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-23DOI: 10.3389/fruro.2024.1380340
Harris Onywera, Ramadhani Salum Chambuso, David J. Benjamin, E. Hilt, K. Thomas-White
{"title":"Editorial: An outlook on urobiome: advances in understanding the role of urobiome in urological health and disease and its potential in biotherapeutics","authors":"Harris Onywera, Ramadhani Salum Chambuso, David J. Benjamin, E. Hilt, K. Thomas-White","doi":"10.3389/fruro.2024.1380340","DOIUrl":"https://doi.org/10.3389/fruro.2024.1380340","url":null,"abstract":"","PeriodicalId":503842,"journal":{"name":"Frontiers in Urology","volume":"29 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140437202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-02-19DOI: 10.3389/fruro.2024.1352701
Carlos Perez−Martinez, Jose Luis Palacios-Galicia, Irma B. Vargas-Diaz, Alvaro Munoz, Yolanda Cruz
This study aimed to investigate the efficacy of six episodes of percutaneous tibial nerve stimulation (PTNS) treatment for overactive bladder (OAB) symptoms in men and women and to determine the duration of the effects over a 6-month period.Women and men with OAB symptoms participated in the study, which was conducted in accordance with an approved ethical protocol (ISRCTN15733799). Patients underwent six 30-min PTNS sessions, twice per week. The symptoms of OAB were assessed using a voiding diary, the short form of the Overactive Bladder Symptom Score questionnaire (OAB-q SF), and the Patient Perception of Bladder Condition (PPBC), which were self-completed by patients before and after treatment (24 h and at 1, 3, and 6 months). The outcome data were compared for sex and time points using two-way ANOVA for repeated measures.PTNS treatment significantly improved the OAB symptoms and quality of life in men and women. PTNS increased the voided volume (p < 0.05) and decreased the frequency of voiding, nocturia, and urgency at 24 h and up to 6 months (p < 0.001). The OABq-SF and PPBC scores were significantly decreased after PTNS (p < 0.001). Urgency was greater in men than in women. The duration of PTNS clinical success on frequency and the perception of improvement in quality of life were greater in women than in men.The clinical effects of six sessions of PTNS strongly suggest its potential for shortening, from the standard 12 sessions, to effectively alleviate symptoms of OAB. This therapeutic procedure would reduce both the time and economic costs of OAB treatment.
{"title":"Efficacy and sex-specific outcomes after six episodes of percutaneous tibial nerve stimulation treatment on overactive bladder syndrome symptoms","authors":"Carlos Perez−Martinez, Jose Luis Palacios-Galicia, Irma B. Vargas-Diaz, Alvaro Munoz, Yolanda Cruz","doi":"10.3389/fruro.2024.1352701","DOIUrl":"https://doi.org/10.3389/fruro.2024.1352701","url":null,"abstract":"This study aimed to investigate the efficacy of six episodes of percutaneous tibial nerve stimulation (PTNS) treatment for overactive bladder (OAB) symptoms in men and women and to determine the duration of the effects over a 6-month period.Women and men with OAB symptoms participated in the study, which was conducted in accordance with an approved ethical protocol (ISRCTN15733799). Patients underwent six 30-min PTNS sessions, twice per week. The symptoms of OAB were assessed using a voiding diary, the short form of the Overactive Bladder Symptom Score questionnaire (OAB-q SF), and the Patient Perception of Bladder Condition (PPBC), which were self-completed by patients before and after treatment (24 h and at 1, 3, and 6 months). The outcome data were compared for sex and time points using two-way ANOVA for repeated measures.PTNS treatment significantly improved the OAB symptoms and quality of life in men and women. PTNS increased the voided volume (p < 0.05) and decreased the frequency of voiding, nocturia, and urgency at 24 h and up to 6 months (p < 0.001). The OABq-SF and PPBC scores were significantly decreased after PTNS (p < 0.001). Urgency was greater in men than in women. The duration of PTNS clinical success on frequency and the perception of improvement in quality of life were greater in women than in men.The clinical effects of six sessions of PTNS strongly suggest its potential for shortening, from the standard 12 sessions, to effectively alleviate symptoms of OAB. This therapeutic procedure would reduce both the time and economic costs of OAB treatment.","PeriodicalId":503842,"journal":{"name":"Frontiers in Urology","volume":"30 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140450200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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