精准基因组编辑:CRISPR 和纳米技术在癌症治疗中的协同作用

Akash Vikal, Rashmi Maurya, Shuvadip Bhowmik, Preeti Patel, Rajveer Singh, Ghanshyam Das Gupta, B. Kurmi
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引用次数: 0

摘要

近年来,CRISPR(Clustered Regularly Interspaced Short Palindromic Repeats)技术的应用给遗传学和分子生物学带来了革命性的变化。它已超越基因编辑的范畴,将创新的癌症治疗和纳米技术方法纳入其中,成为开创性的基因组编辑工具。它已成为抗击癌症的有力工具。通过靶向和修改与肿瘤发生和生长相关的特定基因,CRISPR 提供了一种对抗这种毁灭性疾病的精确手段。研究人员正越来越多地利用 CRISPR 增强癌症疗法,从提高传统疗法的疗效到开发新型免疫疗法。与此同时,纳米技术也为诊断和治疗癌症开辟了新的途径。由于其独特的物理特性,纳米粒子可用于靶向给药和成像,甚至可用作 CRISPR 等基因编辑工具的载体。这些纳米粒子可以在错综复杂的生物环境中穿梭,锁定癌细胞,同时最大限度地减少对健康组织的附带损伤。这种精确性对于减少副作用和提高抗癌药物的治疗潜力至关重要。在这篇综述中,我们强调了 CRISPR 和纳米技术的协同潜力,尤其是在癌症治疗方面,突出了它们在推进免疫疗法方面的宝贵作用。这种纳米技术视角极大地促进了这一领域研究的不断发展。
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Precision Genome Editing: The Synergy of CRISPR and Nanotechnology in Cancer Treatment
In recent years, the applications of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology have revolutionized genetics and molecular biology. It has expanded beyond genetic editing to include innovative cancer treatment and nanotechnology approaches as a ground-breaking genome editing tool. It has emerged as a potent tool in the battle against cancer. By targeting and modifying specific genes associated with tumor development and growth, CRISPR offers a precise means of combating this devastating disease. Researchers are increasingly utilizing CRISPR to enhance cancer therapies, from boosting the efficacy of traditional treatments to developing novel immunotherapies. Simultaneously, nanotechnology, on the other hand, has opened up new avenues in diagnosing and treating cancer. Due to their unique physical properties, nanoparticles can be engineered for targeted drug delivery and imaging and even be used as vehicles for gene-editing tools like CRISPR. These nanoparticles can navigate the intricate biological environment, homing in on cancer cells while minimizing collateral damage to healthy tissue. This precision is essential in reducing side effects and enhancing the therapeutic potential of anticancer agents. In this review, we emphasize the synergistic potential of CRISPR and nanotechnology, particularly in cancer treatment, highlighting their valuable role in advancing immunotherapy approaches. This nanotechnological perspective contributes significantly to the evolving landscape of research in this field
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