光过敏评估的创新战略:在化妆品成分开发中摆脱动物模型的束缚

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cosmetics Pub Date : 2024-03-25 DOI:10.3390/cosmetics11020047
A. S. Maddaleno, M. Vinardell, M. Mitjans
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引用次数: 0

摘要

光过敏是特定化合物在紫外线照射下诱发皮肤过敏的一种独特形式,传统上一直使用动物进行研究。然而,欧洲和其他国家禁止在评估化妆品成分时进行动物试验,这就突出了采用体外或硅学替代方法的必要性。目前,还没有有效的方法来评估光过敏或光敏性,这给新化妆品成分的开发带来了巨大挑战。本综述探讨了检测光敏性的替代方法,重点介绍了近期发表的文章,并考虑了不同拟议检测方法的基本原理。
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Innovative Strategies for Photoallergy Assessment: Breaking Free from Animal Models in Cosmetic Ingredient Development
Photoallergy, a unique form of skin sensitization induced by specific compounds under ultraviolet irradiation, has traditionally been investigated using animals. However, the prohibition of animal testing for the assessment of cosmetic ingredients in Europe and other countries underscores the necessity for in vitro or in silico alternative methods. Currently, there are no validated methods for assessing photoallergy or photosensitization, presenting a significant challenge in the development of new cosmetic ingredients. This review examines the landscape of alternative methods for detecting photosensitization, emphasizing recent publications, and considering the underlying principles of the different proposed assays.
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来源期刊
Cosmetics
Cosmetics Medicine-Surgery
CiteScore
5.20
自引率
12.10%
发文量
108
审稿时长
8 weeks
期刊最新文献
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