化脓性扁桃体炎中巨噬细胞的极化以及巨噬细胞与其他细胞之间的相互影响

Qiujing Zhang, Yibo Feng, Xiang Chen, Xiaohui Mo, Qiong Wu, Qiang Ju
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引用次数: 0

摘要

化脓性扁平湿疹(Hidradenitis suppurativa,HS)又称倒置性痤疮,是一种慢性炎症性疾病,其特征是在腋窝、腹股沟、臀部和肛周等部位出现炎性结节、脓肿和排脓隧道。HS的发病机制尚不清楚,但越来越多的人认识到它依赖于炎症反应的失调。这一过程的核心是巨噬细胞,它们已成为 HS 炎症环境中的关键角色。这些细胞通过极化协调炎症反应,并对邻近细胞的功能产生重大影响。本综述简要介绍了HS患者体内巨噬细胞的极化以及巨噬细胞与其他细胞之间的相互影响,旨在为HS的临床治疗提供新的治疗策略。
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Macrophage Polarization and Crosstalk between Macrophages and Other Cells in Hidradenitis Suppurativa
Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disease characterized by the development of inflammatory nodules, abscesses, and pus-discharging tunnels in areas such as the axillary, inguinal, gluteal, and perianal regions. The pathogenesis of HS remains unclear, but it is being increasingly recognized to rely on the dysregulation of inflammatory responses. Central to this process are macrophages, which have emerged as key players in the inflammatory milieu of HS. These cells orchestrate inflammation via polarization and significantly influence the functions of neighboring cells. This review briefly describes macrophage polarization and crosstalk between macrophages and other cells in patients with HS with the aim of providing new therapeutic strategies for the clinical management of HS.
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