补充维生素 D3 前后重度抑郁症患者的血清胃泌素和瘦素浓度

IF 4.7 2区 医学 Q1 PSYCHIATRY Depression and Anxiety Pub Date : 2024-03-25 DOI:10.1155/2024/2057881
Shareefa AlGhamdi, Nabilah Alsulami, Sawsan Khoja, Hadeil Alsufiani, Haythum O. Tayeb, Huda Alshaibi, Frank I. Tarazi
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引用次数: 0

摘要

目的测定重度抑郁障碍(MDD)患者在补充维生素 D3 前后血清中瘦素和胃泌素的浓度。研究方法本研究共招募了 72 名参与者(40 名重度抑郁症患者和 32 名健康对照组)。MDD通过贝克抑郁量表(BDI)进行诊断。研究开始时采集所有参与者的血样,以确定血清 25(OH)D3、瘦素和胃泌素的基线浓度。然后,患者每周接受一次维生素 D3(50,000 IU)治疗,为期 3 个月,研究结束时再次采集血液样本。研究结果基线时,多发性硬化症患者的血清瘦素浓度明显高于健康对照组。相比之下,血清胃泌素浓度明显低于健康对照组。在补充维生素 D3 三个月后,多发性硬化症患者的病情有所改善,BDI 评分下降,血清维生素 D 和胃泌素浓度上升。补充维生素 D3 对血清瘦素浓度没有影响。结论补充维生素D3的抗抑郁作用可能是由胃泌素而非瘦素介导的。
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Serum Ghrelin and Leptin Concentrations in Patients with Major Depressive Disorder before and after Supplementation with Vitamin D3

Aim. To determine serum concentrations of leptin and ghrelin in patients with major depressive disorder (MDD) before and after vitamin D3 supplementation. Methods. A total of 72 participants were recruited in this study (40 MDD patients and 32 healthy controls). MDD was diagnosed by using Beck’s Depression Inventory (BDI) scale. Blood samples were collected from all participants at the beginning of the study to determine baseline serum 25(OH)D3, leptin, and ghrelin concentrations. Patients were then treated weekly with vitamin D3 (50,000 IU) for 3 months, and blood samples were collected again by the end of the study. Results. At baseline, serum leptin concentrations were significantly higher in MDD patients than in healthy controls. In contrast, serum ghrelin concentrations were significantly lower compared to those in healthy controls. After supplementation with vitamin D3 for three months, MDD patients showed improvements characterized by a decrease in their BDI’s scores and an increase in their serum vitamin D and ghrelin concentrations. No effects of vitamin D3 supplementation were seen on serum leptin concentration. Conclusions. The antidepressant effects of vitamin D3 supplementation could be mediated by ghrelin but not leptin.

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来源期刊
Depression and Anxiety
Depression and Anxiety 医学-精神病学
CiteScore
15.00
自引率
1.40%
发文量
81
审稿时长
4-8 weeks
期刊介绍: Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.
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