{"title":"简化合成:改进莱姆格鲁伯-批次吲哚路线,实现 2,3- 未取代吲哚的一锅串联生产","authors":"Aviraboina Siva Prasad, Talupula Venkateswara Rao","doi":"10.21474/ijar01/18325","DOIUrl":null,"url":null,"abstract":"Aim:This study aims to create a new one-pot synthesis method for substituted indoles, focusing on efficiency, by-product reduction, and comparative advantages over conventional Leimgruber-Batcho reactions. Methods:Researchers optimized a one-pot synthesis strategy for maximum yield, reduced by-products, and resource utilization, comparing it to traditional Leimgruber-Batcho reactions, ensuring a sustainable, environmentally friendly approach. Results:The one-pot synthesis method efficiently produced substituted indoles with reduced environmental impact, yielding more than conventional reactions, shortened reaction times, and aligning with green chemistry principles. Conclusions:The one-pot synthesis method for substituted indoles, using 2-nitrotoluenes and dimethylformamide dimethyl acetal, is a significant advancement in the field, offering improved efficiency, environmental sustainability, and higher yields compared to conventional methods, making it a more resource-effective and economically viable option.","PeriodicalId":13781,"journal":{"name":"International Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"STREAMLINED SYNTHESIS: ENHANCING THE LEIMGRUBER-BATCHO INDOLE ROUTE FOR ONE-POT TANDEM PRODUCTION OF 2,3-UNSUBSTITUTED INDOLES\",\"authors\":\"Aviraboina Siva Prasad, Talupula Venkateswara Rao\",\"doi\":\"10.21474/ijar01/18325\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Aim:This study aims to create a new one-pot synthesis method for substituted indoles, focusing on efficiency, by-product reduction, and comparative advantages over conventional Leimgruber-Batcho reactions. Methods:Researchers optimized a one-pot synthesis strategy for maximum yield, reduced by-products, and resource utilization, comparing it to traditional Leimgruber-Batcho reactions, ensuring a sustainable, environmentally friendly approach. Results:The one-pot synthesis method efficiently produced substituted indoles with reduced environmental impact, yielding more than conventional reactions, shortened reaction times, and aligning with green chemistry principles. Conclusions:The one-pot synthesis method for substituted indoles, using 2-nitrotoluenes and dimethylformamide dimethyl acetal, is a significant advancement in the field, offering improved efficiency, environmental sustainability, and higher yields compared to conventional methods, making it a more resource-effective and economically viable option.\",\"PeriodicalId\":13781,\"journal\":{\"name\":\"International Journal of Advanced Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-02-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Advanced Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21474/ijar01/18325\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Advanced Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21474/ijar01/18325","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
STREAMLINED SYNTHESIS: ENHANCING THE LEIMGRUBER-BATCHO INDOLE ROUTE FOR ONE-POT TANDEM PRODUCTION OF 2,3-UNSUBSTITUTED INDOLES
Aim:This study aims to create a new one-pot synthesis method for substituted indoles, focusing on efficiency, by-product reduction, and comparative advantages over conventional Leimgruber-Batcho reactions. Methods:Researchers optimized a one-pot synthesis strategy for maximum yield, reduced by-products, and resource utilization, comparing it to traditional Leimgruber-Batcho reactions, ensuring a sustainable, environmentally friendly approach. Results:The one-pot synthesis method efficiently produced substituted indoles with reduced environmental impact, yielding more than conventional reactions, shortened reaction times, and aligning with green chemistry principles. Conclusions:The one-pot synthesis method for substituted indoles, using 2-nitrotoluenes and dimethylformamide dimethyl acetal, is a significant advancement in the field, offering improved efficiency, environmental sustainability, and higher yields compared to conventional methods, making it a more resource-effective and economically viable option.