ROLE OF AYURVEDIC MEDICINES ON CARCINOMA GALL BLADDER AFTER CONVENTIONAL ANTI-CANCER THERAPY: A RANDOMISED CONTROL TRIAL

Gallbladder cancer (GBC) arises from the cystic duct and gallbladder lining, presenting as a thickening in the bile duct wall or a diffuse mass. Arbuda and Gulma are considered malignant tumours in Ayurveda. Acharya Charaka associates Gulma, a type of shotha, with the pittashaya (gall bladder) among the five adhishthans. Acharya Sushruta defines Gulma as "any granthi between hruday and Basti pradesh." Aim: To evaluate the efficacy of Ayurvedic medicine on associated signs and symptoms of carcinoma gall bladder following conventional anti-cancer therapy. Objective: To evaluate the QOL of the studied patient of carcinoma gall bladder following conventional anti-cancer therapy. Materials and methods: 20 patients suffering from the associated signs and symptoms of carcinoma gall bladder following conventional anti-cancer therapy were enrolled and randomly divided into two groups, i.e., Study Group B, Brihat Loknath Rasa 250 mg with lukewarm water, Mahashankh vati 250 mg with buttermilk, and Drakshavleha 6 gm with milk. In Control Group A, patients undergoing modern medicine were observed for 60 days. Results and Conclusion: The analysis of the relief percentage of the (Overall therapy) shows that the % relief for Study Group patients was 43.40% and the relief for Control Group was 38.68%. In conclusion, Ayurveda has the potential for symptomatic management of gallbladder cancer (GBC) by aligning with Pitta pradhan sannipatika Gulma. While a holistic approach and Ayurvedic principles show promise, more research in Ayurvedic oncology is required for validation.