接触克百威后小鼠十二指肠的组织病理学概述

Reza Mahendra Yudha Permana, Eka Pramyrtha Hestianah, Widjiati, Maslichah Mafruchati, Budiarto Budiarto, Epy Muhammad Luqman
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引用次数: 0

摘要

本研究的目的是通过对暴露于呋喃丹的小鼠(麝香猫)进行十二指肠组织病理学研究,探讨小肠组织损伤。测量参数是十二指肠上皮的完整性。实验涉及 30 只雌性小鼠,分为四个处理组:P0(对照组)不接触呋喃丹,用0.9%氯化钠代替;P1接触0.0104毫克/千克体重的呋喃丹;P2接触0.0208毫克/千克体重的呋喃丹;P3接触0.0407毫克/千克体重的呋喃丹。实验设计为完全随机设计,四个处理,五个重复。数据分析采用 Kruskal-Wallis 检验,如果处理组之间存在显著差异,则采用 Mann-Whitney 检验。结果表明,接触克百威会引起脱屑和上皮侵蚀,十二指肠组织病理学变化的有效剂量为0.208毫克/千克体重。
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Histopathological overview of mice duodenum (Mus musculus) due to carbofuran exposure
The aim of this study was to explore small bowel tissue injury through duodenal histopathology of mice (Mus musculus) exposed to carbofuran. The measured parameter was duodenal epithelial integrity. The experiment involved thirty female mice, divided into four treatment groups: P0 (control) was not exposed to carbofuran but substituted with 0.9% NaCl; P1 was exposed to 0.0104 mg/kg Body Weight of carbofuran; P2 was exposed to 0.0208 mg/kg Body Weight of carbofuran; P3 was exposed to 0.0407 mg/kg Body Weight of carbofuran. The experimental design was a completely randomized design with four treatments and five replications. Data were analyzed using the Kruskal-Wallis test, followed by the Mann-Whitney test if there were significant differences among treatment groups. The results suggested that carbofuran exposure caused desquamation and epithelial erosion, with the effective dose for duodenal histopathology change being 0.208 mg/kg Body Weight.
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