探索鱼油(欧米茄-3 和欧米茄-6 多不饱和脂肪)作为代谢介质用于癌症靶向治疗的潜力

Isaac Sokoato MOMOH, Micheal Omeyiza IBRAHIM, Victoria Sokolayame EMMANUEL, Emieseimokumo NUMONDE, Peter Ayomide AKOMOLAFE
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引用次数: 0

摘要

在全球范围内,癌症死亡率和发病率都在急剧上升。据 GLOBOCAN 估计,到 2020 年,全球将有约 1 000 万人死于癌症,新增癌症确诊病例近 1 930 万例,癌症将成为全球第一大死因,并严重阻碍预期寿命的提高。虽然癌症无法完全治愈。不过,人们经常服用含有源自海洋的多元不饱和脂肪酸(如 EPA 和 DHA)的补充剂。鱼油(每天 3 克以上)和 EPA/DHA(每天 1 克以上和 0.8 克以上)已被证明具有良好的临床效果,表明它们有可能成为化疗的有效辅助剂,并可减轻癌症的一些有害后果。本综述旨在研究欧米加-3 PUFA 作为代谢介质的重要性及其对癌症的影响。
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Exploring the potential of fish oil (Omega-3 and Omega-6 Polyunsaturated Fats) as metabolic mediators for targeted cancer therapy
Cancer mortality and incidence are both sharply increasing on a global scale. GLOBOCAN estimates that in 2020, there were around 10.0 million cancer-related deaths and nearly 19.3 million new cancer diagnoses, making cancer the top cause of death globally and a significant impediment to improving life expectancy. Cancer cannot be completely cured, though. However, supplements containing polyunsaturated fatty acids with marine origins, such as EPA and DHA, are frequently taken. Fish oil (above 3 grams per day) and EPA/DHA (above 1 and above 0.8 grams per day) have been shown to have good clinical effects, indicating that they may have the potential to be an effective adjuvant to chemotherapy and may alleviate some of the harmful consequences of cancer. This review is aimed at examining the importance of Omega-3 PUFAs as metabolic mediators and their impact on cancer.
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