印度与 COVID-19 相关的粘孢子菌病疫情的结果:为期两年的前瞻性跟踪研究

Vishav Yadav, Sanjeev Bhagat, Khushboo Goel, R. Sibia, D. Sharma, T. Sidhu, Saivi Rajdev, Ankita Aggarwal
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摘要

本研究旨在研究2019年冠状病毒病(COVID-19)相关粘液瘤病(CAM)在发病率和死亡率方面的各种结果。本研究对印度帕蒂亚拉政府医学院耳鼻咽喉头颈外科的107名患者(60名男性,47名女性)进行了前瞻性研究,这些患者在2021年4月至2021年8月期间被诊断为CAM。患者均接受了药物和手术治疗。在 107 名患者中,短期(3 个月)存活率为 68.22%,长期(2 年)存活率为 52.34%。总死亡率为 47.66%,其中短期死亡率为 31.77%,长期死亡率为 15.89%。总之,尽管进行了早期治疗并取得了初步成功,但患者仍被 CAM 的后遗症所困扰,如眼部和腭部缺失、眼球震颤和抑郁等。在两年的随访中,还发现了延迟死亡率。
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Outcomes of COVID‐19‐associated mucormycosis epidemic in India: A prospective 2‐year follow‐up study
The objective of this study was to study the various outcomes among coronavirus disease 2019 (COVID‐19)‐associated mucormycosis (CAM) in terms of morbidity and mortality.A prospective study was done on 107 patients (60 male, 47 female) in the Department of Otolaryngology and Head and Neck Surgery, Government Medical College, Patiala, India, diagnosed with CAM from April 2021 to August 2021. The patients were managed both medically and surgically. The follow‐up was done up to 2 years to assess the various outcomes.Out of 107 patients, short‐term (3 months) survival was 68.22%, and long‐term (2 years) survival was 52.34%. Overall mortality was 47.66%, with short‐term mortality of 31.77% and long‐term mortality of 15.89%. Eye loss was seen in 17 patients, residual ophthalmoplegia in 12, palatal loss in 15, depression in 56, cerebrospinal fluid rhinorrhea in two, and recurrence in two patients.In conclusion, despite early management and successful initial outcome, the patients are still haunted by the after‐effects of CAM like residual morbidity in terms of eye and palate loss, ophthalmoplegia, and depression. Delayed mortality has also been noticed over 2 years of follow‐up.
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