纳米海绵:基于纳米技术的新兴给药系统

Rikhav Shah, Dipika Chavda
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摘要

在当前情况下,医学专家长期以来一直在努力解决如何将药物输送到体内的目标位置,同时控制药物释放率以避免用药过量的问题。这一问题可以通过制造新型、复杂的配方(即纳米海绵)来解决。纳米海绵是一种小型海绵,大小与病毒相当,可容纳多种药物。这些微小的海绵可以在系统中移动,直到到达预定的目标区域,然后附着在表面,开始以稳定和可控的方式释放药物。纳米海绵是一种自发分解的网络或三维聚酯支架。这些聚酯与交联剂在溶液中结合,形成纳米海绵。当装载的纳米海绵框架破裂时,药物颗粒就会释放出来。它们大多呈固体形式,可配制成口服、肠外、局部或吸入剂型,已有多项研究通过纳米颗粒技术对蛋白质、肽、基因、抗癌生物大分子进行了研究,从而减少了不良反应,提高了药效。
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Nano Sponge: An Emerging Nano-Technology Based Drug Delivery System
In current scenario medical experts have long struggled with how to deliver medication to targeted location into the body while also controlling the drug release rate to avoid overdosing. This issue may be resolve through the creation of novel, intricate formulation known as nano sponges. Nano sponges are small sponge, all around size virus, that may hold a range of medication. These microscopic sponges can move through the system until they reach the intended target region, where they adhere to surface and start to release the drug in steady and controlled manner. Nano sponges are a network or 3D polyester scaffold that are spontaneously decompose. These polyesters are combined with cross-linkers agent in a solution to create a nano sponge. When loaded nano sponge’s framework breakdown the drug particle is released. They are mostly in solid form and it can be formulated as oral, parenteral, topical, or inhalation dosage form, several studies havebeen conducted on protein, peptide, genes, anti-cancer biomolecules via nano-particle technology which hep to reduce undesirable effect and enhance efficacy.
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