自身免疫性系统性红斑狼疮(SLE)的药物相互作用

Rosyida Awalia Safitri, William Sayogo, Yenni Muflihan, Nurul Maela, Yuni Wahyuningsih Setiawan, Sita Fauzia Rahma
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引用次数: 0

摘要

影响系统性红斑狼疮等自身免疫性疾病治疗成功与否的因素之一是药物与其他活性化合物的相互作用。有几项研究指出,药物与药物或与其他活性化合物(如草药)之间存在相互作用,这可以支持治疗或抑制药物治疗的效果。本综述旨在研究自身免疫性疾病中的药物相互作用,重点是系统性红斑狼疮(SLE)。采用的方法是系统性综述,文献来源为国际期刊或研究文章,共有 31 篇文章符合纳入标准。有证据表明,治疗系统性红斑狼疮的药物,如非甾体抗炎药(NSAIDs)、皮质类固醇激素和免疫抑制剂之间存在相互作用。此外,还获得了有关系统性红斑狼疮治疗与草本植物(如 Cecendet 或 Physalis angulata L、马尾草)和肥料植物(如 Manjakani、Kacip Fatimah、叶绿素和螺旋藻)之间相互作用的结果,以及系统性红斑狼疮治疗药物与其他类型的系统性红斑狼疮药物和草药之间相互作用的结果,这些相互作用可支持或阻碍药物的治疗效果。
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Drug Interactions in Autoimmune Systemic Lupus Erythematosus (SLE)
One of the factors that influence the success of therapy in autoimmune diseases such as SLE is the interaction of drugs with other active compounds. Several studies have stated that there are drug interactions with drugs or with other active compounds such as herbs which can support therapy or inhibit the effects of drug therapy. This review aims to investigate drug interactions in autoimmune diseases with a focus on systemic lupus erythematosus (SLE). The method used is a systematic review with literature sources in the form of international journals or research articles, and 31 articles met the inclusion criteria. There is evidence of interactions between drugs for the treatment of SLE, such as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and immunosuppressants. In addition, results were obtained regarding the interaction of SLE therapy with herbal plants such as Cecendet or Physalis angulata L, horsetail, and fertilizing plants such as Manjakani, Kacip Fatimah, Chlorophyll, and Spirulina as well as interactions between drugs in both SLE therapies with other types of SLE drugs and with herbal medicine, these interactions can support or hinder the therapeutic effect of the drug
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