分量呼出一氧化碳对睡眠呼吸暂停-低通气综合征患者的影响及其机制。

Quanlin Jia, Li Guo, Xinhua Zheng, Guangwei Li, Lu Liu
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摘要

睡眠呼吸障碍(SDB)是一种常见的睡眠障碍,与慢性气道炎症和肺功能损害有关。本文旨在研究阻塞性睡眠呼吸暂停-低通气综合征(OSAHS)患者呼出一氧化碳(FeCO)的表达水平及其与疾病指标的相关性。研究人员选取了患有 OSAHS、哮喘、慢性阻塞性肺疾病(COPD)和健康的受试者,收集他们的临床数据。研究人员测量了FeCO浓度、嗜酸性粒细胞(Eos)、红细胞沉降率(ESR)、C反应蛋白(CRP)、FEV1和FEV1/FVC。采用皮尔逊相关系数和接收者操作特征曲线(ROC)进行统计分析。OSAHS 组的 FeCO 浓度、Eos 计数、血沉和 CRP 水平以及肺功能均高于健康组和 COPD 组(P<0.05),略低于哮喘组。FeCO 与 Eos、ESR 和 CRP 呈正相关(P<0.05),但 FeCO 与肺功能无明显相关性。在诊断 OSAHS 时,FeCO 具有较高的敏感性和特异性。OSAHS 患者存在慢性气道炎症和全身炎症。OSAHS 患者的肺功能损伤较轻,但仍存在一些局限性。FeCO可能是一种辅助诊断指标,尤其对诊断OSAHS有重要价值。
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Effect of fractional exhaled carbon monoxide on patients with sleep apnea-hypopnea syndrome and its mechanism.
Sleep-disordered breathing (SDB) is a common sleep disorder as-sociated with chronic airway inflammation and lung function impairment. This article aimed to investigate the fractional exhaled carbon monoxide (FeCO) expression level in obstructive sleep apnea-hypopnea syndrome (OSAHS) and its correlation with disease indicators. Subjects with OSAHS, asthma, chronic obstructive pulmonary disease (COPD), and healthy subjects were selected to collect clinical data. FeCO concentration, eosinophil (Eos), erythrocyte sed-imentation rate (ESR), C-reactive protein (CRP), FEV1, and FEV1/FVC were measured. The Pearson correlation coefficient and receiver operating charac-teristic (ROC) curve were used for statistical analysis. The FeCO concentra-tion, Eos count, ESR and CRP levels, and lung function in the OSAHS group were higher than the healthy and COPD groups (p<0.05) and slightly lower than the asthma group. FeCO was positively correlated with Eos, ESR, and CRP (p<0.05), but there was no apparent correlation between FeCO and lung func-tion. FeCO has a high sensitivity and specificity in the diagnosis of OSAHS. There is chronic airway inflammation and systemic inflammation in patients with OSAHS. Lung function impairment in patients with OSAHS is mild, but some limitations remain. FeCO may be an auxiliary diagnostic index particu-larly valuable in diagnosing OSAHS.
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