Allen Hung, J. Gutiérrez, Janelle Gasia, Yusmary Gil, José Guanipa, Julio Castro, A. Reigosa, Ángel Fernández
Breast carcinoma of the triple-negative subtype (TNBC) does not express estrogen, progesterone or human epidermal growth factor recep-tor 2 (HER2) receptors. A subclassification of TNBC has been proposed into four subgroups, one of which is the luminal androgen receptor. The objective of this work was to determine the expression of the androgen receptor (AR) in women with TNBC, diagnosed by immunohistochemistry, at the Hospital Metropolitano del Norte, Valencia, Venezuela. The sample consisted of 191 pa-tients who met the inclusion criteria. The mean age of the patients at the time of diagnosis was 54.91 years. Histologically, the majority of the tumors were moderately differentiated or undifferentiated. The percentage of AR expres-sion was 22% (42 of 191). In the association between AR expression and the Ki-67 proliferative index, a greater number of AR positive cases was observed in tumors with Ki-67 expression of less than 40%. The AR positivity found in this study represents an intermediate frequency in relation to other investigations. No statistically significant differences were found with the age of the patients and histological grade of the tumors, while the Ki-67 proliferative index was lower for AR+ tumors, compared to TNBC in general.
三阴性亚型乳腺癌（TNBC）不表达雌激素、孕激素或人类表皮生长因子受体 2（HER2）受体。有人提出将 TNBC 划分为四个亚组，其中一个是腔内雄激素受体亚组。这项研究的目的是确定在委内瑞拉巴伦西亚北大都会医院（Hospital Metropolitano del Norte）通过免疫组化确诊的 TNBC 女性患者中雄激素受体（AR）的表达情况。样本包括191名符合纳入标准的患者。患者确诊时的平均年龄为 54.91 岁。从组织学角度来看，大多数肿瘤属于中度分化或未分化。AR表达率为22%（191例中有42例）。在AR表达与Ki-67增殖指数之间的关系中，Ki-67表达低于40%的肿瘤中AR阳性病例较多。与其他研究相比，本研究发现的 AR 阳性率属于中等水平。与一般TNBC相比，AR+肿瘤的Ki-67增殖指数较低，但与患者的年龄和肿瘤的组织学分级没有统计学差异。
{"title":"Expresión de receptores de andrógeno en pacientes con carcinoma de mama del subtipo triple negativo.","authors":"Allen Hung, J. Gutiérrez, Janelle Gasia, Yusmary Gil, José Guanipa, Julio Castro, A. Reigosa, Ángel Fernández","doi":"10.54817/ic.v65n1a06","DOIUrl":"https://doi.org/10.54817/ic.v65n1a06","url":null,"abstract":"Breast carcinoma of the triple-negative subtype (TNBC) does not express estrogen, progesterone or human epidermal growth factor recep-tor 2 (HER2) receptors. A subclassification of TNBC has been proposed into four subgroups, one of which is the luminal androgen receptor. The objective of this work was to determine the expression of the androgen receptor (AR) in women with TNBC, diagnosed by immunohistochemistry, at the Hospital Metropolitano del Norte, Valencia, Venezuela. The sample consisted of 191 pa-tients who met the inclusion criteria. The mean age of the patients at the time of diagnosis was 54.91 years. Histologically, the majority of the tumors were moderately differentiated or undifferentiated. The percentage of AR expres-sion was 22% (42 of 191). In the association between AR expression and the Ki-67 proliferative index, a greater number of AR positive cases was observed in tumors with Ki-67 expression of less than 40%. The AR positivity found in this study represents an intermediate frequency in relation to other investigations. No statistically significant differences were found with the age of the patients and histological grade of the tumors, while the Ki-67 proliferative index was lower for AR+ tumors, compared to TNBC in general.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"229 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Appendicitis is an inflammation of the appendix that, if left un-treated, can be life-threatening. Abdominal ultrasound helps diagnose it and differentiate it from other causes of abdominal pain. This study aimed to evalu-ate the diagnostic value of abdominal ultrasound in acute appendicitis (AA) and assess inflammatory factor levels in different types of appendicitis. One hundred patients with AA were selected as the observation group, and 30 pa-tients with simple abdominal pain as the control group. Among the 100 AA patients, 37 (37%) cases had blurred appendiceal boundaries, 24 (24%) cases had fecal calculus in the appendix cavity, 13 (13%) cases had enhanced echo intensity of surrounding fat, 15 (15%) cases presented enlarged outer diameter of the appendix (> 6mm), one (1%) case had peripheral lymphadenopathy, and one (1%) case had peripheral effusion. None of the cases (0%) presented a pe-ripheral mass. The levels of white blood cells (WBC) and inflammatory factors: C-reactive protein (CRP), interleukin-6 (IL -6), and tumor necrosis factor α(TNF-α)) patients with uncomplicated appendicitis were lower than those with suppurative appendicitis, gangrenous appendicitis, or peri-appendiceal abscess (p <0.05). The blurred boundary of the appendix, fecal stones in the appendix cavity, an enlarged outer diameter of the appendix (> 6mm), and an enhanced echogenicity of the surrounding fat are the most common ultrasonic signs of AA. Abdominal ultrasound has an excellent diagnostic value on pathological types of AA. The increase in the level of inflammatory factors can indicate the severity of the disease to a certain extent.
阑尾炎是阑尾的一种炎症，如果不及时治疗，可能会危及生命。腹部超声波有助于诊断阑尾炎，并将其与其他原因引起的腹痛区分开来。本研究旨在评估腹部超声波对急性阑尾炎（AA）的诊断价值，并评估不同类型阑尾炎的炎症因子水平。研究选取 100 名急性阑尾炎患者作为观察组，30 名单纯腹痛患者作为对照组。在 100 例 AA 患者中，37 例（37%）阑尾边界模糊，24 例（24%）阑尾腔内有粪便结石，13 例（13%）阑尾周围脂肪回声强度增强，15 例（15%）阑尾外径增大（> 6 毫米），1 例（1%）阑尾周围淋巴结肿大，1 例（1%）阑尾周围渗液。没有一个病例（0%）出现阑尾肿块。白细胞（WBC）和炎症因子的水平：无并发症阑尾炎患者的白细胞（WBC）和炎症因子：C 反应蛋白（CRP）、白细胞介素-6（IL-6）和肿瘤坏死因子α（TNF-α）的水平低于化脓性阑尾炎、坏疽性阑尾炎或阑尾周围脓肿患者（P 6mm），周围脂肪的回声增强是 AA 最常见的超声波征象。腹部超声对病理类型的 AA 有很好的诊断价值。炎症因子水平的升高可在一定程度上显示疾病的严重程度。
{"title":"Diagnostic value of abdominal ultrasound in patients with acute appendicitis and analysis of the expression of related inflammatory factors.","authors":"Siyuan Yang, Mingyan Wang, Linxin Yang, Ning Lin","doi":"10.54817/ic.v65n1a03","DOIUrl":"https://doi.org/10.54817/ic.v65n1a03","url":null,"abstract":"Appendicitis is an inflammation of the appendix that, if left un-treated, can be life-threatening. Abdominal ultrasound helps diagnose it and differentiate it from other causes of abdominal pain. This study aimed to evalu-ate the diagnostic value of abdominal ultrasound in acute appendicitis (AA) and assess inflammatory factor levels in different types of appendicitis. One hundred patients with AA were selected as the observation group, and 30 pa-tients with simple abdominal pain as the control group. Among the 100 AA patients, 37 (37%) cases had blurred appendiceal boundaries, 24 (24%) cases had fecal calculus in the appendix cavity, 13 (13%) cases had enhanced echo intensity of surrounding fat, 15 (15%) cases presented enlarged outer diameter of the appendix (> 6mm), one (1%) case had peripheral lymphadenopathy, and one (1%) case had peripheral effusion. None of the cases (0%) presented a pe-ripheral mass. The levels of white blood cells (WBC) and inflammatory factors: C-reactive protein (CRP), interleukin-6 (IL -6), and tumor necrosis factor α(TNF-α)) patients with uncomplicated appendicitis were lower than those with suppurative appendicitis, gangrenous appendicitis, or peri-appendiceal abscess (p <0.05). The blurred boundary of the appendix, fecal stones in the appendix cavity, an enlarged outer diameter of the appendix (> 6mm), and an enhanced echogenicity of the surrounding fat are the most common ultrasonic signs of AA. Abdominal ultrasound has an excellent diagnostic value on pathological types of AA. The increase in the level of inflammatory factors can indicate the severity of the disease to a certain extent.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"118 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This narrative review analyzed the relationship between cervical cancer and the vaginal microbiome. It has been estimated that viruses and bac-teria cause 15% of all cancers. The development of molecular biology, genetics, and the use of high-throughput genomic sequencing techniques has allowed us not only to know the phenotypic component but also the genetic component of the vaginal microbiome and obtain a better knowledge and understanding of the behavior of the vaginal flora that was previously impossible to determine. The relation of the alterations in the vaginal flora by women’s habits, immunological status, and socioeconomic level has been established. Literature searches were performed electronically in PubMed, Medline, ISI, DOAJ, Springer, Embase, Web of Knowledge, and Google Scholar for original articles written in English and Sci-elo, Latindex, Imbiomed-L, Redalyc, and Google Scholar for original articles writ-ten in Spanish. The objective of this narrative review was to examine and analyze the literature on the alterations in the vaginal microbiome, their local protective effect and their possible contribution to the development of cervical cancer.
这篇叙述性综述分析了宫颈癌与阴道微生物组之间的关系。据估计，15% 的癌症是由病毒和细菌引起的。分子生物学、遗传学的发展以及高通量基因组测序技术的使用，使我们不仅能够了解阴道微生物组的表型成分，还能了解其遗传成分，并对以前无法确定的阴道菌群行为有了更好的认识和理解。阴道菌群的改变与妇女的生活习惯、免疫状态和社会经济水平之间的关系已经确定。通过电子方式在 PubMed、Medline、ISI、DOAJ、Springer、Embase、Web of Knowledge 和 Google Scholar 搜索英文原文，并在 Sci-elo、Latindex、Imbiomed-L、Redalyc 和 Google Scholar 搜索西班牙文原文。这篇叙述性综述的目的是研究和分析有关阴道微生物组的改变、其局部保护作用以及可能导致宫颈癌发生的文献。
{"title":"Microbiota vaginal y cáncer de cuello uterino.","authors":"José Núñez-Troconis, Antonio Molero","doi":"10.54817/ic.v65n1a10","DOIUrl":"https://doi.org/10.54817/ic.v65n1a10","url":null,"abstract":"This narrative review analyzed the relationship between cervical cancer and the vaginal microbiome. It has been estimated that viruses and bac-teria cause 15% of all cancers. The development of molecular biology, genetics, and the use of high-throughput genomic sequencing techniques has allowed us not only to know the phenotypic component but also the genetic component of the vaginal microbiome and obtain a better knowledge and understanding of the behavior of the vaginal flora that was previously impossible to determine. The relation of the alterations in the vaginal flora by women’s habits, immunological status, and socioeconomic level has been established. Literature searches were performed electronically in PubMed, Medline, ISI, DOAJ, Springer, Embase, Web of Knowledge, and Google Scholar for original articles written in English and Sci-elo, Latindex, Imbiomed-L, Redalyc, and Google Scholar for original articles writ-ten in Spanish. The objective of this narrative review was to examine and analyze the literature on the alterations in the vaginal microbiome, their local protective effect and their possible contribution to the development of cervical cancer.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"155 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The main achievement of the journal in 2023 was an increase in the number of works received, mainly of foreign origin. The rejection percentage was 36%. The evaluation of the work of the members of the Editorial Committee had the collaboration of external referees from national and foreign institutions, especially Venezuelans living abroad. The magazine fulfilled its frequency of four issues with 41 communications in 559 pages, exceeding the number of pages from the previous year. Among the 41 works, the original works in English predominated, both from Venezuela and Latin America and countries on other continents. In evaluating the magazine by international indices, the increase in the Copernicus Index score stands out due to excellent compliance with their classification patterns. There were discrepancies between the different indexes in the citations; Clarivate reported 204, and Sco-pus only 20. Scopus recognizes only 44 citations in the four years (2019-2022), and Scielo recognizes 498 in that same period. The Crossref report was of more than 13,000 accesses in 2023, with Spanish-language Reviews being the most frequent, which suggests that Latin America is the primary source of readers for the magazine. This observation corroborates the results of our website, where the main accesses come from American countries. We hope that in 2024, Investigación Clínica will increase its national and international recognition; it would be a gift to the memory of its founder, Américo Negrette, who would be celebrating the centenary of his birth in 2024.
{"title":"EDITORIAL\u0000Alcances de la revista Investigación Clínica durante el año 2023.","authors":"E. Ryder","doi":"10.54817/ic.v65n1a00","DOIUrl":"https://doi.org/10.54817/ic.v65n1a00","url":null,"abstract":"The main achievement of the journal in 2023 was an increase in the number of works received, mainly of foreign origin. The rejection percentage was 36%. The evaluation of the work of the members of the Editorial Committee had the collaboration of external referees from national and foreign institutions, especially Venezuelans living abroad. The magazine fulfilled its frequency of four issues with 41 communications in 559 pages, exceeding the number of pages from the previous year. Among the 41 works, the original works in English predominated, both from Venezuela and Latin America and countries on other continents. In evaluating the magazine by international indices, the increase in the Copernicus Index score stands out due to excellent compliance with their classification patterns. There were discrepancies between the different indexes in the citations; Clarivate reported 204, and Sco-pus only 20. Scopus recognizes only 44 citations in the four years (2019-2022), and Scielo recognizes 498 in that same period. The Crossref report was of more than 13,000 accesses in 2023, with Spanish-language Reviews being the most frequent, which suggests that Latin America is the primary source of readers for the magazine. This observation corroborates the results of our website, where the main accesses come from American countries. We hope that in 2024, Investigación Clínica will increase its national and international recognition; it would be a gift to the memory of its founder, Américo Negrette, who would be celebrating the centenary of his birth in 2024.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"58 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate the correlation between cogni-tive dysfunction and emotional state in patients with Alzheimer’s disease and then propose intervention strategies. One hundred twenty-five patients with Alzheimer’s disease from June 2019 to May 2022 were selected as the study subjects and divided into two groups based on the degree of cognitive impair-ment, both receiving routine drug treatment and cognitive rehabilitation in-tervention. The Montreal Cognitive Assessment (MoCA) and the Positive and Negative Affect Scale (PANAS) were used to evaluate the cognitive function and emotional status of two groups of patients before the intervention and four and eight weeks of intervention and to analyze the correlations between the two. The results showed statistically significant differences between the two groups MoCA and PANAS scores (P<0.05). Before the intervention, the patient’s MoCA score was positively correlated with the PANAS positive emo-tion score and negatively correlated with the PANAS negative emotion score (P<0.05). After four and eight weeks of intervention, the patient’s MoCA score was positively correlated with the PANAS positive emotion score (P<0.05) and negatively correlated with the PANAS negative emotion score (P<0.05).
本研究旨在探讨阿尔茨海默病患者认知功能障碍与情绪状态的相关性，进而提出干预策略。选取2019年6月至2022年5月的125例阿尔茨海默病患者作为研究对象，根据认知障碍程度分为两组，均接受常规药物治疗和认知康复干预。采用蒙特利尔认知评估（MoCA）和正负情量表（PANAS）对两组患者干预前、干预4周和8周的认知功能和情绪状态进行评估，并分析两者之间的相关性。结果显示，两组患者的 MoCA 和 PANAS 评分差异有统计学意义（P<0.05）。干预前，患者的MoCA得分与PANAS的积极情绪得分呈正相关，与PANAS的消极情绪得分呈负相关（P<0.05）。干预四周和八周后，患者的 MoCA 评分与 PANAS 积极情绪评分呈正相关（P<0.05），与 PANAS 消极情绪评分呈负相关（P<0.05）。
{"title":"Correlation between the degree of cognitive impairment and emotional state in patients with Alzheimer’s disease.","authors":"Zhichao Qiu, Jingjing Cai, Fanlin Xia","doi":"10.54817/ic.v65n1a04","DOIUrl":"https://doi.org/10.54817/ic.v65n1a04","url":null,"abstract":"This study aimed to investigate the correlation between cogni-tive dysfunction and emotional state in patients with Alzheimer’s disease and then propose intervention strategies. One hundred twenty-five patients with Alzheimer’s disease from June 2019 to May 2022 were selected as the study subjects and divided into two groups based on the degree of cognitive impair-ment, both receiving routine drug treatment and cognitive rehabilitation in-tervention. The Montreal Cognitive Assessment (MoCA) and the Positive and Negative Affect Scale (PANAS) were used to evaluate the cognitive function and emotional status of two groups of patients before the intervention and four and eight weeks of intervention and to analyze the correlations between the two. The results showed statistically significant differences between the two groups MoCA and PANAS scores (P<0.05). Before the intervention, the patient’s MoCA score was positively correlated with the PANAS positive emo-tion score and negatively correlated with the PANAS negative emotion score (P<0.05). After four and eight weeks of intervention, the patient’s MoCA score was positively correlated with the PANAS positive emotion score (P<0.05) and negatively correlated with the PANAS negative emotion score (P<0.05).","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"171 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Elma, B. Suleyman, R. Mammadov, B. Yavuzer, Edhem Unver, D. Altuner, T. Coban, Behzat Mokhtare, H. Suleyman
Favipiravir is a broad-spectrum antiviral drug that is a viral RNA-dependent RNA polymerase inhibitor. Favipiravir is used in high doses to treat COVID-19 but has a side effect on humans at high doses. The side effects of favipiravir have been associated with oxidative stress in the literature. In this trial, we investigated the biochemical and histopathological effects of lacidip-ine, thiamine pyrophosphate (TTP), and adenosine triphosphate (ATP), drugs with antioxidant properties, on the lung toxicity caused by high-dose favipiravir in rats. The rats were classified into five groups: healthy (HG), favipiravir alone (Fav), lacidipine+favipiravir (LFav), TPP+favipiravir (TFav), and ATP+favipiravir (AFav). Favipiravir (800 mg/kg) was administered twice daily for seven days. Laci-dipine (4 mg/kg), TPP (20 mg/kg), and ATP (25 mg/kg) were administered once daily for seven days. Oxidant (malondialdehyde), non-enzymatic (total glutathi-one), and enzymatic (superoxide dismutase and catalase) antioxidant levels were measured in the excised lung tissues. Furthermore, the tissues were histopatho-logically examined. The systemic administration of high doses of favipiravir in-creased oxidant levels and decreased antioxidant levels in the lung tissue of rats. In parallel, the histopathological examination of the lung tissue revealed the presence of severe mononuclear cell infiltrations in interstitial areas and pronounced lymphoid hyperplasia. Lacidipine exhibited superior efficacy in mit-igating oxidative stress and preventing the decline of antioxidants induced by favipiravir compared with TPP and ATP. Histopathologically, the lacidipine admin-istration significantly reduced lung oxidative damage. TTP moderately reduced severe favipiravir-associated lung injury. However, ATP was ineffective against fa-vipiravir-associated lung injury. Lacidipine offers more therapeutic benefits than TPP in treating oxidative lung injury caused by high doses of favipiravir.
{"title":"Pulmonary toxicity associated with high-dose favipiravir and treatment options: biochemical and histopathological evaluation.","authors":"B. Elma, B. Suleyman, R. Mammadov, B. Yavuzer, Edhem Unver, D. Altuner, T. Coban, Behzat Mokhtare, H. Suleyman","doi":"10.54817/ic.v65n1a08","DOIUrl":"https://doi.org/10.54817/ic.v65n1a08","url":null,"abstract":"Favipiravir is a broad-spectrum antiviral drug that is a viral RNA-dependent RNA polymerase inhibitor. Favipiravir is used in high doses to treat COVID-19 but has a side effect on humans at high doses. The side effects of favipiravir have been associated with oxidative stress in the literature. In this trial, we investigated the biochemical and histopathological effects of lacidip-ine, thiamine pyrophosphate (TTP), and adenosine triphosphate (ATP), drugs with antioxidant properties, on the lung toxicity caused by high-dose favipiravir in rats. The rats were classified into five groups: healthy (HG), favipiravir alone (Fav), lacidipine+favipiravir (LFav), TPP+favipiravir (TFav), and ATP+favipiravir (AFav). Favipiravir (800 mg/kg) was administered twice daily for seven days. Laci-dipine (4 mg/kg), TPP (20 mg/kg), and ATP (25 mg/kg) were administered once daily for seven days. Oxidant (malondialdehyde), non-enzymatic (total glutathi-one), and enzymatic (superoxide dismutase and catalase) antioxidant levels were measured in the excised lung tissues. Furthermore, the tissues were histopatho-logically examined. The systemic administration of high doses of favipiravir in-creased oxidant levels and decreased antioxidant levels in the lung tissue of rats. In parallel, the histopathological examination of the lung tissue revealed the presence of severe mononuclear cell infiltrations in interstitial areas and pronounced lymphoid hyperplasia. Lacidipine exhibited superior efficacy in mit-igating oxidative stress and preventing the decline of antioxidants induced by favipiravir compared with TPP and ATP. Histopathologically, the lacidipine admin-istration significantly reduced lung oxidative damage. TTP moderately reduced severe favipiravir-associated lung injury. However, ATP was ineffective against fa-vipiravir-associated lung injury. Lacidipine offers more therapeutic benefits than TPP in treating oxidative lung injury caused by high doses of favipiravir.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"65 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Quanlin Jia, Li Guo, Xinhua Zheng, Guangwei Li, Lu Liu
Sleep-disordered breathing (SDB) is a common sleep disorder as-sociated with chronic airway inflammation and lung function impairment. This article aimed to investigate the fractional exhaled carbon monoxide (FeCO) expression level in obstructive sleep apnea-hypopnea syndrome (OSAHS) and its correlation with disease indicators. Subjects with OSAHS, asthma, chronic obstructive pulmonary disease (COPD), and healthy subjects were selected to collect clinical data. FeCO concentration, eosinophil (Eos), erythrocyte sed-imentation rate (ESR), C-reactive protein (CRP), FEV1, and FEV1/FVC were measured. The Pearson correlation coefficient and receiver operating charac-teristic (ROC) curve were used for statistical analysis. The FeCO concentra-tion, Eos count, ESR and CRP levels, and lung function in the OSAHS group were higher than the healthy and COPD groups (p<0.05) and slightly lower than the asthma group. FeCO was positively correlated with Eos, ESR, and CRP (p<0.05), but there was no apparent correlation between FeCO and lung func-tion. FeCO has a high sensitivity and specificity in the diagnosis of OSAHS. There is chronic airway inflammation and systemic inflammation in patients with OSAHS. Lung function impairment in patients with OSAHS is mild, but some limitations remain. FeCO may be an auxiliary diagnostic index particu-larly valuable in diagnosing OSAHS.
{"title":"Effect of fractional exhaled carbon monoxide on patients with sleep apnea-hypopnea syndrome and its mechanism.","authors":"Quanlin Jia, Li Guo, Xinhua Zheng, Guangwei Li, Lu Liu","doi":"10.54817/ic.v65n1a09","DOIUrl":"https://doi.org/10.54817/ic.v65n1a09","url":null,"abstract":"Sleep-disordered breathing (SDB) is a common sleep disorder as-sociated with chronic airway inflammation and lung function impairment. This article aimed to investigate the fractional exhaled carbon monoxide (FeCO) expression level in obstructive sleep apnea-hypopnea syndrome (OSAHS) and its correlation with disease indicators. Subjects with OSAHS, asthma, chronic obstructive pulmonary disease (COPD), and healthy subjects were selected to collect clinical data. FeCO concentration, eosinophil (Eos), erythrocyte sed-imentation rate (ESR), C-reactive protein (CRP), FEV1, and FEV1/FVC were measured. The Pearson correlation coefficient and receiver operating charac-teristic (ROC) curve were used for statistical analysis. The FeCO concentra-tion, Eos count, ESR and CRP levels, and lung function in the OSAHS group were higher than the healthy and COPD groups (p<0.05) and slightly lower than the asthma group. FeCO was positively correlated with Eos, ESR, and CRP (p<0.05), but there was no apparent correlation between FeCO and lung func-tion. FeCO has a high sensitivity and specificity in the diagnosis of OSAHS. There is chronic airway inflammation and systemic inflammation in patients with OSAHS. Lung function impairment in patients with OSAHS is mild, but some limitations remain. FeCO may be an auxiliary diagnostic index particu-larly valuable in diagnosing OSAHS.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"90 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chronic atrophic gastritis (CAG) is a precancerous atrophic gastritis of the stomach, which generates an urge to develop novel therapeu-tic schedules. This study aimed to investigate the effect of experimental folic acid administration on N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)-induced CAG through the PI3K/Akt pathway in rats. The rats were divided into a Model Group, a Folic Acid Group and a Blank Group. Rats in the Model Group were induced by MNNG and given 10 mL/kg/d distilled water by gavage, while rats in the Folic Acid Group were induced by MNNG and given 5 mg/kg/d folic acid suspension by gavage. As a control, rats in the Blank Group were given the same amount of distilled water as MNNG and 10 mL/kg/d distilled water by gavage. The levels of gastrin (GAS) and motilin (MTL) in serum were measured by enzyme-linked immunosorbent assay (ELISA), and the mRNA and protein ex-pressions were detected by quantitative polymerase chain reaction (q-PCR) and Western blot. According to hematoxylin and eosin (H&E) pathological analysis, there were inflammatory factors infiltration and derangement of mucosal epi-thelial cells in the model group, while the gastric tissue injury in the folic acid group was improved. Folic acid could decrease the content of GAS, increase the content of MTL in the serum of the rats, and regulate the expression of PI3K and AKT signal pathways. Folic acid can have a therapeutic effect on CAG by reducing the concentration of GAS in serum and increasing the concentration of MLT in serum. Our study would lay a theoretical foundation for using folic acid to investigate new therapies for CAG in humans.
{"title":"The mechanism of folic acid on N-methyl-N’-nitro-N-nitrosoguanidine-induced chronic atrophic gastritis through the PI3K/Akt pathway.","authors":"Yun An, Weigang Chen, Yong Cao, Boshen Chen, Qiangbin Li, Xia Zhou, Weihan Huang","doi":"10.54817/ic.v65n1a05","DOIUrl":"https://doi.org/10.54817/ic.v65n1a05","url":null,"abstract":"Chronic atrophic gastritis (CAG) is a precancerous atrophic gastritis of the stomach, which generates an urge to develop novel therapeu-tic schedules. This study aimed to investigate the effect of experimental folic acid administration on N-methyl-N’-nitro-N-nitrosoguanidine (MNNG)-induced CAG through the PI3K/Akt pathway in rats. The rats were divided into a Model Group, a Folic Acid Group and a Blank Group. Rats in the Model Group were induced by MNNG and given 10 mL/kg/d distilled water by gavage, while rats in the Folic Acid Group were induced by MNNG and given 5 mg/kg/d folic acid suspension by gavage. As a control, rats in the Blank Group were given the same amount of distilled water as MNNG and 10 mL/kg/d distilled water by gavage. The levels of gastrin (GAS) and motilin (MTL) in serum were measured by enzyme-linked immunosorbent assay (ELISA), and the mRNA and protein ex-pressions were detected by quantitative polymerase chain reaction (q-PCR) and Western blot. According to hematoxylin and eosin (H&E) pathological analysis, there were inflammatory factors infiltration and derangement of mucosal epi-thelial cells in the model group, while the gastric tissue injury in the folic acid group was improved. Folic acid could decrease the content of GAS, increase the content of MTL in the serum of the rats, and regulate the expression of PI3K and AKT signal pathways. Folic acid can have a therapeutic effect on CAG by reducing the concentration of GAS in serum and increasing the concentration of MLT in serum. Our study would lay a theoretical foundation for using folic acid to investigate new therapies for CAG in humans.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"384 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study investigated the factors affecting the prognosis of patients with traumatic brain injury (TBI) and assessed the predictive value of intracranial pressure-related parameters and coagulation on prognosis. Seventy TBI patients admitted between January 2020 and January 2021 were catego-rized into good prognosis (n=42) and poor prognosis (n=28) groups according to the Glasgow Outcome Scale (GOS) score upon discharge. Factors affecting prognosis were analyzed, and differences in intracranial pressure and coagula-tion between the two groups were compared. The receiver operating charac-teristic curve (ROC) was used to calculate the predictive value of intracranial pressure-related parameters and coagulation function on prognosis. Within 24 h postoperatively, the good prognosis group had lower levels of intracra-nial pressure (ICP) and partial pressure of oxygen in brain tissue (PbtO2) and higher cerebral perfusion pressure (CPP) and cerebral hemodynamic param-eters than the poor prognosis group (p<0.05). The good prognosis group had significantly lower prothrombin time (PT), activated partial thromboplastin time (aPTT),and prothrombin time (TT) levels and higher platelets (PLT) and fibrinogen (Fib) levels than the poor prognosis group (p<0.05). Regression analysis revealed that CPP, systolic blood flow velocity (Vs), end-diastolic blood flow velocity (Vd), mean blood flow velocity (Vm), PLT, Fib were independent protective factors for the prognosis, and ICP, PbtO2, PT, APTT, and TT were risk factors for prognosis. The ROC revealed that ICP, CPP, PbtO2, Vs, Vd, Vm, APTT, PLT, Fib exhibited high diagnostic value for poor prognosis (AUC=0.732, 0.940, 0.796, 0.706, 0.914, 0.729, 0.876, 0.709, 0.866), with ICP showing the highest diagnostic sensitivity and Vd showing the highest diagnostic specificity. Intracranial pressure-related parameters and coagulation indicators are prog-nosis-related indexes in patients with TBI, and the prognosis and survival can be improved by controlling intracranial pressure and improving coagulation.
{"title":"Predictive value of intracranial pressure-related parameters and coagulation on the prognosis in patients with traumatic brain injury.","authors":"Linna Shen, Haibin Lu, Shuibo Yang, Feixiong Chen","doi":"10.54817/ic.v65n1a02","DOIUrl":"https://doi.org/10.54817/ic.v65n1a02","url":null,"abstract":"This study investigated the factors affecting the prognosis of patients with traumatic brain injury (TBI) and assessed the predictive value of intracranial pressure-related parameters and coagulation on prognosis. Seventy TBI patients admitted between January 2020 and January 2021 were catego-rized into good prognosis (n=42) and poor prognosis (n=28) groups according to the Glasgow Outcome Scale (GOS) score upon discharge. Factors affecting prognosis were analyzed, and differences in intracranial pressure and coagula-tion between the two groups were compared. The receiver operating charac-teristic curve (ROC) was used to calculate the predictive value of intracranial pressure-related parameters and coagulation function on prognosis. Within 24 h postoperatively, the good prognosis group had lower levels of intracra-nial pressure (ICP) and partial pressure of oxygen in brain tissue (PbtO2) and higher cerebral perfusion pressure (CPP) and cerebral hemodynamic param-eters than the poor prognosis group (p<0.05). The good prognosis group had significantly lower prothrombin time (PT), activated partial thromboplastin time (aPTT),and prothrombin time (TT) levels and higher platelets (PLT) and fibrinogen (Fib) levels than the poor prognosis group (p<0.05). Regression analysis revealed that CPP, systolic blood flow velocity (Vs), end-diastolic blood flow velocity (Vd), mean blood flow velocity (Vm), PLT, Fib were independent protective factors for the prognosis, and ICP, PbtO2, PT, APTT, and TT were risk factors for prognosis. The ROC revealed that ICP, CPP, PbtO2, Vs, Vd, Vm, APTT, PLT, Fib exhibited high diagnostic value for poor prognosis (AUC=0.732, 0.940, 0.796, 0.706, 0.914, 0.729, 0.876, 0.709, 0.866), with ICP showing the highest diagnostic sensitivity and Vd showing the highest diagnostic specificity. Intracranial pressure-related parameters and coagulation indicators are prog-nosis-related indexes in patients with TBI, and the prognosis and survival can be improved by controlling intracranial pressure and improving coagulation.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"473 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This retrospective study compared the clinical outcomes and prognostic factors in acute myocardial infarction-related patients with inter-ventricular septal perforation (AMI-VSP) who underwent interventional occlu-sion (IO group) or surgical intervention (SI group). Forty-six patients were ana-lyzed based on comprehensive clinical data, laboratory results, and follow-up evaluations. The SI group had higher EuroScore II scores and more patients in Killip class IV. Both treatments showed improved laboratory indices, but the IO group had higher left ventricular ejection fraction and lower levels of specific biomarkers. The postoperative hospital stay and total hospitalization time were shorter in the IO group. Survival rates did not significantly differ between the two groups during the follow-up period. Logistic regression analysis identified a history of coronary heart disease as a significant risk factor affecting progno-sis and survival rates. Both interventional occlusion and surgical intervention proved effective, with IO showing faster recovery and more favorable prognoses, while surgery was preferred for severe cases. Coronary heart disease was a key factor influencing postoperative survival in AMI-VSP patients.
{"title":"Comparison of clinical efficacy and prognosis between interventional occlusion and surgical treatment for acute myocardial infarction with ventricular septal perforation.","authors":"Chenyao Ni, Peng Hu, Yiming Ni","doi":"10.54817/ic.v65n1a07","DOIUrl":"https://doi.org/10.54817/ic.v65n1a07","url":null,"abstract":"This retrospective study compared the clinical outcomes and prognostic factors in acute myocardial infarction-related patients with inter-ventricular septal perforation (AMI-VSP) who underwent interventional occlu-sion (IO group) or surgical intervention (SI group). Forty-six patients were ana-lyzed based on comprehensive clinical data, laboratory results, and follow-up evaluations. The SI group had higher EuroScore II scores and more patients in Killip class IV. Both treatments showed improved laboratory indices, but the IO group had higher left ventricular ejection fraction and lower levels of specific biomarkers. The postoperative hospital stay and total hospitalization time were shorter in the IO group. Survival rates did not significantly differ between the two groups during the follow-up period. Logistic regression analysis identified a history of coronary heart disease as a significant risk factor affecting progno-sis and survival rates. Both interventional occlusion and surgical intervention proved effective, with IO showing faster recovery and more favorable prognoses, while surgery was preferred for severe cases. Coronary heart disease was a key factor influencing postoperative survival in AMI-VSP patients.","PeriodicalId":14515,"journal":{"name":"Investigación Clínica","volume":"122 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140453286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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